Cartilage Diseases and Arthritis Biomarker Detection Service
Creative BioMart Biomarker is one of the experts who are professional in biomarker detection. We have years of biomarker detection experience and advanced detection methods and detection instruments to provide fast, sensitive and repeatable bone formation biomarker detection services according to customer needs. Our services also include bone formation biomarker detection services and bone resorption biomarker detection services.
Introduction
Cartilage which is a connective tissue without blood vessels, nerve and lymph, is an important component of synovial joint. Cartilage can be divided into three categories according to the difference of intercellular substance, which are hyaline cartilage, fibrocartilage and elastic cartilage. Chondrocytes are the only cells exist in cartilage that are embedded in the extracellular matrix (ECM). Cartilage ECM is synthesized by chondrocytes and consists of a collagenous network, which is composed of type II collagen, glycosaminoglycans (GAGs) and various proteoglycans. Impaired cartilage integrity not only affects its function, but also adversely affects the state or metabolic activity of neighboring cells and tissues. Cartilage plays a variety of roles in the human body, including the loading of joints and intervertebral discs, the lubrication of joints, the support of the trachea, etc. Due to the important position of cartilage in the human body, there are many kinds of diseases related to cartilage, including developmental disorders, osteochondritis dissecans, Relapsing polychondritis, chondrocalcinosis, osteoarthritis (OA) and rheumatoid arthritis (RA). Since there is no nerve in the cartilage, symptoms usually appear only after the matrix structure is severely damaged. Therefore, the application of biomarkers in cartilage disease is of great significance. Arthritis is a disease that develops in a large number of people, and its main symptoms are joint pain and stiffness. There are more than 100 types of arthritis, the most common of which are OA and RA. OA is the most common joint disease associated with a variety of risk factors, including aging, joint trauma, and obesity. RA is a complex inflammatory disease associated with autoimmunity. Various biomarkers related to cartilage diseases and arthritis have been found, such as hyaluronic acid (HA), high motility group box 1 protein (HMGB1), cartilage oligomeric matrix protein (COMP), chondroitin sulfate 846 epitope (CS846), etc.
Figure 1. Schematic of the Knee Joint, Showing the Synovial Joint Tissues Affected in Osteoarthritis (Hunter, 2015)
Creative BioMart Biomarker offers a wide range of cartilage diseases and arthritis related biomarker detection based on customer needs. Through advanced instruments, we accept different samples of different concentrations and ensure a wide kinetic range to detect samples of different concentrations. In addition, different biomarkers have different detection effects in different samples, we can customize the detection plan according to customer needs, and obtain the ideal test results with appropriate samples and advanced detection methods.
Our Advantages
- Guarantee high accuracy and sensitivity for single biomarker detection
- Ensure high repeatability of single biomarker detection
- Short turn-around time of detection service
- Competitive price in the market of detection services
- Provide multiple detection methods
- Accept a wide range of sample types
Our Single Biomarker Detection Services Related to Cartilage Diseases and Arthritis:
Workflow of Biomarker Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the single biomarker detection procedure to ensure accurately quantify the level of each biomarker.
At Creative BioMart Biomarker, we not only provide high quality cartilage diseases and arthritis biomarker detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design a proper technological scheme according to your specific requirements. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Pap, T.; Korb-Pap, A. Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings. Nature Reviews Rheumatology. 2015, 11(10): 606-615.
- Yamini, K.; Grodzinsky, A.J. Cartilage diseases. Matrix Biology. 2017.
- Nefla, M.; et al. The danger from within: alarmins in arthritis. Nature Reviews Rheumatology. 2016, 12(11): 669-683.
- Hunter, D.J. Viscosupplementation for Osteoarthritis of the Knee. The New England Journal of Medicine. 2015, 372(11): 1040-7.
