Liver Injury Biomarker Detection Service

There are many types of liver injury, affecting human health and life safety. The introduction of biomarkers is conducive to the diagnosis of liver injury, disease progression monitoring and prognostic analysis. As a leader in biomarker research, Creative BioMart Biomarker has multiple advanced biomarker detection technology platforms and several technically experienced technical teams. We provide customers with a variety of liver injury related biomarker detection services to help customers advance research progress and shorten the research cycle.

Introduction

The liver is an important organ of the human body, with powerful metabolic functions and detoxification functions. Liver injury can be divided into chronic liver injury and acute liver injury, among which chronic liver injury includes steatosis, fibrosis, cirrhosis and cancer, and acute liver injury includes drug-induced liver injury or cholestasis. Persistent liver damage occurs in steatohepatitis, viral hepatitis, and autoimmune, drug or alcohol-induced hepatitis. Among them, drug-induced liver injury is one of the main causes of acute and chronic liver diseases. Because the liver is the main organ of drug metabolism, most drugs entering the human body need to be metabolized by the liver, and in the process of drug metabolism, toxic substances may be produced and damage the liver. Therefore, drug toxicity studies are needed in drug development, and hepatic toxicity caused by drugs has hindered the development of new drugs. Drug-induced liver injury is the main cause of adverse drug reactions and drug withdrawal or restricted use. How to evaluate the liver injury risk of preclinical drugs more accurately is particularly important for new drug development and clinical risk control. Biomarkers play an indicator role for physiological conditions, disease states and pharmacological reactions. Therefore, biomarkers have been a very direct and effective technical means for detecting liver injury. There are already some liver injury biomarkers with a long history of research, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST). However, their sensitivity and specificity for liver injury are not high, and they cannot effectively promote the prognostic analysis of liver injury. Therefore, there is an urgent need to find new and effective liver injury biomarkers in order to accurately detect liver injury and hepatotoxicity.

Figure 1. Progression of chronic liver disease (McGill, et al. 2016)

Creative BioMart Biomarker offers a wide range of liver injury related biomarker detection based on customer needs. Through advanced instruments, we accept different samples of different concentrations and ensure a wide kinetic range to detect samples of different concentrations. In addition, different biomarkers have different detection effects in different samples, we can customize the detection plan according to customer needs, and obtain the ideal test results with appropriate samples and advanced detection methods.

Our Advantages

• Guarantee high accuracy and sensitivity for single biomarker detection
• Ensure high repeatability of single biomarker detection
• Short turn-around time of detection service
• Competitive price in the market of detection services
• Provide multiple detection methods
• Accept a wide range of sample types

Our Single Biomarker Detection Services Related to Liver Injury (including but not limited to the following):

Workflow of Single Biomarker Detection at Creative BioMart Biomarker

Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of biomarkers related to liver injury in each sample.

At Creative BioMart Biomarker, we not only provide high-quality liver injury biomarker detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design a proper technological scheme according to your specific requirements. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.

References:

1. Kullak-Ublick, G. A.; et al. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut. 2017, 66(6): 1154-1164.
2. Aithal, G. P.; et al. Biomarkers in liver disease: emerging methods and potential applications. International Journal of Hepatology. 2012, 2012: 437508.
3. McGill, M. R.; et al.Mechanistic Biomarkers in Liver Diseases. In: Preedy V. (eds) Biomarkers in Liver Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht, 2016.