Bone remodeling is a dynamic physiological process of bone, which includes bone resorption and bone formation. Osteoclasts and osteoblasts are the main cells involved in bone remodeling, and this process is related to the balance between bone resorption and bone formation. Imbalances in bone remodeling can lead to a variety of diseases such as arthritis and osteoporosis. A large number of biomarkers that can be used to indicate the bone remodeling process and its associated diseases have been discovered. Creative BioMart Biomarker provides testing services for these biomarkers to ensure high detection efficiency and accuracy for test results.
In vertebrates, bone is a dynamic tissue that maintains bone homeostasis by keeping a balance between bone resorption and bone formation. Bone remodeling is a process that is always present in vertebrate, during this process, damaged bone tissue is removed from the bone through bone resorption, and then new bone tissue is formed by bone formation, in this way healthy bone stays in a steady state. Bone remodeling is a complex process involving cells such as osteoblasts, osteoclasts, osteocytes, and immune cells, among them, osteoblasts, which are developed from mesenchymal stem cells (MSC), are capable of secreting bone matrix proteins and occurring bone mineralization. Osteoclasts, on the other hand, are large multinucleated bone cells that remove the mineralized bone matrix at the damaged site. Bone remodeling consists primarily of five phases, which are activation, resorption, reversal, formation, and mineralization. Bone remodeling can help the body repair damaged bone and maintain bone stability, therefore, bone remodeling imbalance can affect bone function and cause disease. There are many types of diseases related to bone remodeling, including arthritis, osteoporosis, multiple myeloma, and Paget’ disease. A variety of factors are involved in the regulation of bone remodeling, some of which can be used as biomarkers for bone remodeling and its related diseases for they can indicate physiological changes in bone. The detection of bone remodeling biomarkers can help further research on the mechanism of bone remodeling and bone disease, as well as contribute to the early diagnosis of these diseases, the development of treatment guidelines, and the management of disease prognosis. Creative BioMart Biomarker provides detection services for a variety of bone remodeling biomarkers to help you with these studies, for instance, bone alkaline phosphatase (BAP), C-terminal telopeptide of type I collagen (CTX- I), and receptor activator for nuclear factor B ligand (RANK-L).
Figure 1. Basic multicellular unit remodeling on an endosteal surface begins with osteoclasts resorbing mineralized bone matrix (Kostenuik, et al. 2013)
Creative BioMart Biomarker strictly controls each specific experimental step in the single biomarker detection procedure to ensure accurately quantify the level of each biomarker.
At Creative BioMart Biomarker, we offer bone remodeling and diseases biomarkers detection services that include several technical platforms, you can communicate with our experts according to your research needs, and we will determine the final detection technological scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.