The analysis of lipoprotein cholesterol level cannot satisfy the research of cardiovascular disease. High-density lipoprotein (HDL) functionality is considered to have a correlation with atherosclerotic cardiovascular disease, and can be used to assess the risk of developing cardiovascular disease, such as assessing the risk of developing cardiovascular disease in patients with type 1 diabetes. Creative BioMart Biomarker provides biomarker detection services related to HDL functionality, and provides high-quality outsourcing services for researchers in the field of HDL functionality and cardiovascular disease.
Cardiovascular disease has always been a common disease worldwide and a major cause of death. There are many manifestations of cardiovascular disease, such as coronary heart disease, hypertension and stroke, and all manifestations have the common feature of atherosclerosis. Atherosclerosis refers to fatty plaques on the walls of arteries, which can develop silently in the body and eventually lead to cardiovascular disease. Therefore, early monitoring of atherosclerosis is helpful to reduce the risk of cardiovascular disease. HDL is an auxiliary indicator included in cardiovascular health monitoring. And HDL functions such as its anti-inflammatory or pro-inflammatory properties are more sensitive in indicating atherosclerosis. HDL particles have anti-atherosclerotic properties, and they play an important role in reverse cholesterol transport (RCT). They can mediate direct RCT, help clear excess cholesterol present in surrounding blood vessels, and transport them back to the liver for processing. In addition, HDL also has the functions of preventing LDL oxidation, anti-inflammatory, anti-thrombosis, preventing ischemia-reperfusion injury, endothelial protection and regulating glucose metabolism. Lecithin–cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP) and PON-1 are all HDL functional biomarkers. Among them, LCAT and CETP are the key enzymes involved in lipoprotein remodeling and RCT, and paraoxonase 1 (PON1) is related to HDL’s prevention of LDL oxidation. In addition, cholesterol efflux capacity can also be used to evaluate HDL functions.
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of biomarkers related to HDL functionality in each sample.
At Creative BioMart Biomarker, we not only provide high-quality HDL functionality biomarker detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design a proper technological scheme according to your specific requirements. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.