Lipoprotein plays an important role in the development and progression of various diseases, and is a biomarker for various diseases, such as cardiovascular disease and diabetes mellitus. As an expert in the field of biomarkers, Creative BioMart Biomarker provides various technical services related to biomarkers. Our technical team has extensive experience in the detection of single biomarkers, can provide customers with high-quality and efficient detection services, ensure the repeatability and accuracy of test results, and help customer shorten the research cycle.
Lipoprotein is a complex compound formed by the combination of lipids and proteins. It is a type of spherical particles containing a hydrophobic core composed of cholesterol esters and triglycerides, and surrounded by a hydrophilic membrane composed of apolipoproteins, phospholipids and free cholesterol. In lipoproteins, there is no covalent bond between the lipid and the protein, and most of them are combined through hydrophobic interaction between the non-polar part of the lipid and the protein component. Structural properties of lipoproteins make hydrophobic lipids compatible with the aqueous environment of body fluids. Besides, many important transport proteins, structural proteins and enzymes are lipoproteins, so they play an important role in the packaging, storage, transportation and metabolism of mammalian extracellular lipids. Lipoproteins are mainly synthesized in the intestines and liver, and can circulate in the blood system. According to its density, lipoproteins can be divided into chylomicrons (CM), very-low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL). Lipoproteins have important effects on lipid metabolism, such as triacylglycerol metabolism and cholesterol metabolism, and the abnormal expression of lipoproteins may represent the risk of certain diseases. Abnormal lipoprotein metabolism may be observed in diabetes mellitus, kidney disease, and hypothyroidism. In addition, lipoprotein is also regarded as a risk factor for atherosclerotic cardiovascular disease, and plays a key role in the development and progression of atherosclerosis and cardiovascular disease. Therefore, lipoproteins are regarded as a class of proteins with research significance in the field of biomarkers, and have development potential in the treatment and diagnosis of many diseases.
Figure 1. General structure of a lipoprotein (Wasan, et al. 2008)
Creative BioMart Biomarker strictly controls each specific experimental step in the single biomarker detection procedure to ensure accurately quantify the level of each biomarker.
At Creative BioMart Biomarker, we offer lipoprotein biomarkers detection services that include several technical platforms, you can communicate with our experts according to your research needs, and we will determine the final detection technological scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.