Bone Resorption Biomarker Detection Service
Creative BioMart Biomarker is one of the experts who are professional in biomarker detection. We have years of biomarker detection experience and advanced detection methods and detection instruments to provide fast, sensitive and repeatable bone resorption biomarker detection services according to customer needs. Our services also include bone formation biomarker detection services and cartilage diseases and arthritis biomarker detection services.
Introduction
Our bones are constantly undergoing bone remodeling in response to mechanical loads, micro-damage repair and mineral homeostasis. Bone remodeling is a cyclical process necessary for bone growth and consists of four phases: absorption, reversal, formation, and a resting phase. In resorption phase, Stromal cells and osteoblasts express RANKL and M-CSF, RANKL and M-CSF interact with receptors on monocytes/macrophages to induce a commitment to the osteoclast phenotype. Differentiated osteoclasts are polarized on the bone surface, a process that requires a matrix-derived signal transmitted by avb3 integrin. After the formation of the ruffled membrane, osteoclasts acidify the extracellular microenvironment by a proton pump mediated by H+–adenosine triphosphatase (H+-ATPase). The intracellular microenvironment secretes HCl to the resorptive microenvironment via HCO3-/Cl- exchange, maintaining the pH around 4.5. This acidic environment first mobilizes bone minerals, and then the demineralized organic components of the bone are degraded by cathepsin K. An increase in bone resorption leads to a decrease in bone mass. Bone formation exceeds resorption during childhood, and bone resorption exceeds bone formation with increasing age. Biomarker reflects bone resorption activity from bone release to blood. Therefore, biomarker is generally used to predict bone-related diseases and to detect bone resorption. Bone resorption biomarker mainly includes CTX, DKK-1, DPD, ICTP, NTX, Phosphorus, PYD, RANKL, SOST, and TRACP-5b.
Figure 1. Bone resorption pathway.
Creative BioMart Biomarker offers a wide range of bone resorption related biomarker detection based on customer needs. Through advanced instruments, we accept different samples of different concentrations and ensure a wide kinetic range to detect samples of different concentrations. In addition, different biomarkers have different detection effects in different samples, we can customize the detection plan according to customer needs, and obtain the ideal test results with appropriate samples and advanced detection methods.
Our Advantages
- Accept a wide range of sample types
- Provide multiple detection methods
- Ensure high sensitivity for detecting in different samples
- Ensure high accuracy and repeatable detection
- Ensure a wide kinetic range to detect samples of different concentrations
- Short experimental period
Our Single Biomarker Detection Services Related to Bone Resorption:
Workflow of Biomarker Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure high sensitivity, high accuracy and repeatable bone resorption biomarker detection.
Please feel free to contact us if you would like to know more about bone resorption biomarker detection. At Creative BioMart Biomarker, we not only provide high-quality bone resorption biomarker detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design a proper technological scheme according to your specific requirements.
Reference:
- Teitelbaum, S.L. Bone resorption by osteoclasts. Science. 2000, 289(5484): 1504-8.
