SOST is a secreted glycoprotein that is mainly expressed by osteocytes as a negative regulator of bone formation. SOST is a marker of mature osteocytes, and its expression gradually increases as osteocytes mature and acquire intact molecular features. SOST plays an important role in bone homeostasis, and lack of SOST causes increase bone formation, leads to high bone mass human syndrome Van Buchem disease and sclerosteosis. Creative BioMart Biomarker is capable to provide our customers with superior SOST detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
Introduction
Sclerostin (SOST) is a 190 aa secreted glycoprotein, which is mainly expressed in bone matrix and cartilage matrix, and can inhibit the mineralization of osteoblasts in cell culture environment. It belongs to the DAN family of bone morphogenetic protein (BMP) antagonist. SOST inhibits osteoblastogenesis and preosteocyte differentiation of osteoblasts. SOST inhibits bone formation primarily by inhibiting the Wnt/β-catenin signaling pathway, and its expression is regulated by mechanical unloading and oestrogen deficiency. The Wnt/β-catanin signaling pathway is critical for the differentiation and proliferation of osteoblasts. Osteocytes secrete SOST, which regulates bone turnover by responding to mechanical unloading or oestrogen deficiency. SOST inhibits bone formation by inhibiting osteogenic differentiation of mesenchymal stem cells or osteoprogenitor cells and proliferation of osteoblasts. At the same time, SOST can also stimulate osteocytes to secrete RANKL to induce osteoclasts formation, thereby increasing bone resorption. In the human body, serum levels of SOST increase with age and are inversely correlated with bone turnover markers. The highly specific expression pattern and unique bone phenotype make SOST an effective target for the treatment of osteoporosis and the promotion of fracture repair.
Figure 1. The role of SOST in bone resorption.
Application of SOST
- SOST level can be used as a marker to predict Van Buchem disease and osteoporosis.
Our Advantages
- Accept a wide range of sample types
- Ensure high sensitivity for detecting SOST in different samples
- Ensure high accuracy and repeatable SOST detection
- Ensure a wide kinetic range to detect samples of different concentrations
- Short experimental period
Workflow of SOST Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the SOST detection procedure to ensure high sensitivity, high accuracy and repeatable SOST detection.
Please feel free to contact us if you would like to know more about SOST detection. At Creative BioMart Biomarker, we not only provide high-quality SOST detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.
References:
- Suen, P.K.; Qin, L. Sclerostin, an emerging therapeutic target for treating osteoporosis and osteoporotic fracture. Journal of Orthopaedic Translation. 2016, 4:1-13.
- Sebastian, A.; Loots G.G. Transcriptional control of Sost in bone. Bone. 2017, 96:76-84.
- Delgado-Calle, J.; et al. Role and mechanism of action of Sclerostin in bone. Bone. 2017, 96:29-37.
