Anti-CCP Detection Service

Rheumatoid arthritis (RA) is a chronic debilitating inflammatory disease that primarily affects the body’s joints, surrounding tissues, and other extra-articular structures. RA can cause destruction of bone and cartilage, which can lead to severe disability, and it is characterized by rheumatoid factor (RF) present in serum. Anti-CCP is another serum biomarker for the diagnosis of RA with higher sensitivity and specificity. Creative BioMart Biomarker is capable to provide our customers with superior ANTI-CCP detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.

Introduction

RA is one of the most common chronic inflammatory diseases, with 2.4% of people >65 years of age having RA and the prevalence increases with age. Destructive and deformed arthritis can seriously impair patient function and reduce the quality of life of patients. Patients with RA have a poor prognosis, and early diagnosis plays an important role in improving RA, and is highly effective in reducing joint damage, delaying radiation progression, and reducing dysfunction. Anti-citrullinated peptide antibodies (ACPAs) and rheumatoid factor (RF) are serum markers of RA. ACPAs include anticyclic citrullinated peptide (anti-CCP), anti-mutated citrullinated vimentin (anti-MCV), anti-centriolin antibody (anti-CEP-1), among which anti-CCP is the most widely used. Anti-CCP antibody and RF are autoantibodies that promote inflammatory reactions and have a crucial role in RA pathogenesis. The report on RA diagnostic studies compared anti-CCP with other RA biomarkers in terms of sensitivity and specificity. The results show that Anti-CCP antibody positivity was more specific than IgM RF, IgG RF, or IgA RF positivity for rheumatoid Arthritis and was more specific than IgM RF for early rheumatoid arthritis. In addition, serum anti-CCP antibodies help distinguish RA from other types of arthritis, help identify patients at risk of serious disease, and rarely find it in other autoimmune diseases.

The role of anti-CCP in bone resorption.Figure 1. The role of anti-CCP in bone resorption.

Application of anti-CCP

  • Serum anti-CCP level is a biomarker for the diagnosis of RA with higher sensitivity and specificity.

Our Advantages

  • Ensure high sensitivity for detecting anti-CCP in different samples
  • Ensure high accuracy and repeatable anti-CCP detection
  • Ensure a wide kinetic range to detect samples of different concentrations
  • Short experimental period

Workflow of anti-CCP Detection at Creative BioMart Biomarker

Creative BioMart Biomarker strictly controls each specific experimental step in the anti-CCP detection procedure to ensure high sensitivity, high accuracy and repeatable anti-CCP detection.

Anti-CCP Detection Service

Please feel free to contact us if you would like to know more about anti-CCP detection. At Creative BioMart Biomarker, we not only provide high-quality anti-CCP detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.

References:

  1. Zhu, J.N.; et al. Meta-analysis: compared with anti-CCP and rheumatoid factor, could anti-MCV be the next biomarker in the rheumatoid arthritis classification criteria? Clin Chem Lab Med. 2019, doi: 10.1515/cclm-2019-0167.
  2. Nishimura, K.; et al. Meta-analysis: diagnostic accuracy of anti–Cyclic Citrullinated Peptide antibody and rheumatoid factor for rheumatoidarthritis. Ann Intern Med. 2007, 146: 797-808.
  3. Iranshahi, N.; et al. Investigating the relationship between rheumatoid factor and anticyclic citrullinate peptide with FoxP3 gene expression in patients with rheumatoid arthritis. Int J BioMed Public Health. 2018, 1(1): 6-11.

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