RFs Detection Service

Rheumatoid factors (RFs) are a class of autoantibodies that reacts with autoimmunoglobulins of human. RFs mainly include three isotypes, which are IgM RF, IgG RF and IgA RF, and have been used as diagnostic biomarkers for rheumatoid arthritis (RA). Creative BioMart Biomarker offers high quality detection service for RFs, ensuring high detection accuracy, sensitivity and efficiency for each sample.


RFs are a class of autoantibodies originally discovered in RA more than half a century ago. RFs are non-specific that are present not only in RA patients, but also in healthy elderly or in patients with other autoimmune and infectious diseases. However, as the name of the RFs indicates, it is a biomarker commonly used in RA and has always been one of the classification criteria for RA. Its subtypes facilitate the management of RA patients, including diagnosis of RA, provision of prognostic information, prediction of drug response, and identification of subgroups of patients. Secondly, RFs can be used not only to predict the onset of RA but also to predict the development of RA. IgM, IgA and IgG RFs may be detected for many years before the onset of RA. In addition, studies have shown that the appearance order of these three isoforms in serum before diagnosis is first IgM RF, then IgA RF, and finally IgG RF. Moreover, RFs have high detection sensitivity and specificity in RA patients. RFs are a class of immunoglobulins with different subtypes and affinities, of which IgM RFs are the most commonly detected subtypes in RA patients, IgG, IgA, IgE and IgD RFs can also be detected in RA patients. IgM, IgA and IgG RFs can be detected in 52% of RA patients, and they are detected less than 5% in other patients with connective tissue disease. RFs can bind to self-IgG to form an immune complex (IC), which activates the complement system and destructive inflammation, leading to synovial damage and eventually RA. Therefore, RFs are important for guiding the clinical treatment of RA because RFs can not only predict disease progression, but also serve as prognostic indicators.

immunological role of RFs in rheumatoid arthritisFigure 1. The immunological role of RFs in rheumatoid arthritis (Ingegnoli, et al. 2013)

Application of RFs Detection

  • Serum and plasma RFs levels as biomarkers to predict bone diseases, such as rheumatoid arthritis

Our Advantages

  • Guarantee high accuracy and sensitivity for RFs detection
  • Ensure high repeatability of RFs detection
  • Short turn-around time of detection service
  • Competitive price in the market of detection services
  • Accept a wide range of sample types (serum, plasma, etc.)

Detection Technologies


Workflow of RFs Detection at Creative BioMart Biomarker

Creative BioMart Biomarker strictly controls each specific experimental step in the RFs detection procedure to ensure accurately quantify the level of RFs in each sample.

RFs Detection Service

At Creative BioMart Biomarker, we not only provide high-quality RFs s detection service, but also provide detection services for other biomarkers. You can communicate with our experts according to your research needs, and we will determine the final detection technological scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.


  1. Ingegnoli, F.; et al. Rheumatoid factors: clinical applications. Disease markers. 2013, 35(6): 727-734.
  2. Brink, M.; et al. Rheumatoid factor isotypes in relation to antibodies against citrullinated peptides and carbamylated proteins before the onset of rheumatoid arthritis. Arthritis Research & Therapy. 2016, 18(1): 43-53.


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