Glycomics Service for Biomarker Analysis
Glycans are a rapidly growing field of biological sciences focused on the study of glycans, complex sugar molecules found on the surface of cells and proteins. These complex structures play critical roles in a variety of biological processes, including cellular communication, immune response, and disease development. Understanding the glycome has emerged as a promising avenue for biomarker analysis, providing new insights into disease diagnosis, prognosis, and treatment. As an expert in the field of biomarkers, Creative BioMart Biomarker provides customers with comprehensive glycomics services to advance the research of carbohydrate biomarkers.
The Role of Glycomics in Biomarker Analysis
Glycoomics explores the complex language of sugars and attempts to decode the messages conveyed by glycans. As biomarkers, glycans provide valuable information about the health status of an organism and can serve as indicators of disease onset, progression, or response to treatment.
By analyzing the glycome, researchers can identify specific glycan patterns associated with certain diseases, paving the way for the development of novel diagnostic tools and targeted therapies. Glycomics shows great promise in disease diagnosis and prognosis. For example, alterations in glycan profiles are observed in a variety of cancers.
Figure 1. Common glycoconjugates in mammalian cells. (Guo, Y.; et al. 2022)
Glycomics Services Offered by Creative BioMart Biomarker
As a leading company in biological research, Creative BioMart Biomarker provides cutting-edge glycomics services for biomarker analysis. Our state-of-the-art facilities and expertise enable us to provide comprehensive glycomics solutions according to our clients' needs.
MS-based techniques, such as matrix-assisted laser desorption/ionization (MALDI-MS) and electrospray ionization (ESI-MS), provide high sensitivity for the analysis of complex glycan mixtures. MALDI-MS combined with time-of-flight (TOF) MS enables fast scanning over a wide mass-to-charge ratio (m/z) range, which facilitates the detection of low-abundance glycans. ESI-MS combined with techniques such as high performance liquid chromatography (HPLC) can separate and characterize glycopeptides and glycan structures.
Glycan labeling technology enhances the detection and characterization of glycans. By introducing specific tags or labels, such as fluorescent dyes or stable isotopes, researchers can increase the sensitivity and selectivity of glycomics analysis. In addition, analytical methods such as MS and lectin microarrays allow high-throughput screening of glycan structures and their interactions.
Glycan array technology provides a high-throughput platform for studying glycan-protein interactions. By immobilizing different glycan structures onto solid supports, researchers can screen for specific protein-binding partners. This approach provides valuable insights into the functional roles of glycans and their potential as biomarkers.
The Flow of Glycomics Service
Our Advantages
- Our expertise in sample preparation, glycan analysis, and data analysis ensures accurate and reliable results.
- Our continuous investment in advanced instrumentation, including advanced mass spectrometers, HPLC systems, and high-throughput glycan analysis platforms, enables us to deliver high-quality results to our customers.
- Provide customized glycomics solutions according to the specific needs of customers to ensure that the obtained data effectively meet the research goals.
Glycomics reveals the complex language of sugars and reveals disease mechanisms and therapeutic strategies. At Creative BioMart Biomarker, we are committed to advancing glycomics research and providing cutting-edge services, please feel free to contact us for service details.
Reference:
- Guo, Y.; et al. Cancer glycomics offers potential biomarkers and therapeutic targets in the framework of 3P medicine. Front Endocrinol (Lausanne). 2022, 13: 970489.
