Glycan array technology has become a powerful tool for studying glycans and their interactions, providing a comprehensive high-throughput platform for biomarker discovery. Creative BioMart Biomarker provides customers with comprehensive glycan array technology to facilitate biomarker research.
What is a Glycan Array?
Glycan array is a technology that can analyze the interaction between glycans and various biomolecules such as proteins, antibodies and cells. Glycans are complex carbohydrates found on the surface of cells and play crucial roles in various biological processes such as cell adhesion, immune response and cell signaling. By studying the interactions between glycans and other biomolecules, it is possible to gain insight into the complex mechanisms behind diseases and identify potential biomarkers.
Figure 1. Glycans immobilized on a microarray are displayed in a multivalent manner like cell surface glycans. (Hyun, J.Y.; et al. 2017)
Application of Glycan Arrays in Biomarker Research
Glycan array technology offers multiple applications in biomarker research, changing the way we identify and understand disease-associated molecular signatures.
Glycan array analysis enables the identification of specific glycan patterns associated with a variety of diseases, from cancer to autoimmune and infectious diseases. By analyzing glycan-protein interactions, researchers can identify disease-specific glycan signatures as potential diagnostic or prognostic biomarkers.
Glycan Array Services Offered by Creative BioMart Biomarker
With years of industry experience and advanced infrastructure, Creative BioMart Biomarker is able to provide comprehensive and reliable glycan array solutions for biomarker research. We provide one-stop glycan array services to connect upstream and downstream research faster.
- Glycan Synthesis: Synthesize or obtain diverse glycan libraries. We employ cutting-edge technology to ensure the synthesis of high-quality glycans with structural diversity.
- Immobilization: Immobilization of the synthesized glycans on a solid support such as a glass slide or microarray. This spatial organization of glycans allows simultaneous analysis of multiple interactions. Our experts utilize a variety of immobilization techniques to ensure optimal array performance.
- Sample Preparation: Samples are labeled with detection labels to visualize and quantify glycan-protein interactions. We employ advanced sample preparation techniques to optimize sensitivity and specificity, thereby increasing the accuracy of assays.
- Array Incubation: Labeled samples are incubated with immobilized glycans on the array. This enables biomolecules to selectively bind specific glycans, forming glycan-protein complexes.
- Washing and Detection: After the incubation period, the array is carefully washed to remove unbound or non-specifically bound molecules, thereby reducing background noise. Bound complexes are then detected using imaging or scanning techniques, capturing interaction patterns for further analysis.
Our Advantages
- The diverse glycan library allows us to offer a wide range of glycan analysis options, maximizing the opportunity to identify novel biomarkers and glycan-protein interactions.
- Enables high-throughput analysis, enabling simultaneous screening of multiple interactions on a single array.
- Provide tailor-made solutions to meet specific research goals.
Workflow of Glycan Array Service
Glycan array technology provides a powerful platform for understanding the complex world of glycans and their interactions. By leveraging this technology, researchers can unravel disease-specific glycan signatures, accelerating the development of diagnostics, therapeutics, and drugs. With its expertise and advanced infrastructure, Creative BioMart Biomarker is ready to collaborate with scientists around the world to provide customized glycan array services for biomarker discovery.
Contact us today to explore the possibilities of glycan array technology in biomarker research and take your research to new heights.
Reference:
- Hyun, J.Y.; et al. The Glycan Microarray Story from Construction to Applications. Acc Chem Res. 2017, 50(4): 1069-1078.
