Tandem MS (MS/MS) Service
Tandem mass spectrometry (MS/MS) has transformed the field of biomarker analysis, providing a powerful tool for the identification and quantification of proteins and peptides in complex biological samples. With years of industry expertise, Creative BioMart Biomarker has been working to advance biomarker research using MS/MS.
What is MS/MS?
MS/MS is a technique that combines two stages of mass spectrometry to provide enhanced analytical capabilities. It involves the selection, fragmentation, and subsequent analysis of specific ions to obtain detailed structural and compositional information on biomolecules.
In the first stage of MS/MS, specific ions of interest are separated and fragmented. In the second stage, the product ions are further analyzed to determine their mass-to-charge ratios and intensities. This information is then used to identify and quantify the biomolecules present in the sample.
Figure 1. Overview of analysis by MS/MS (Neagu, A.N.; et al. 2022)
Application of MS/MS in Biomarker Analysis
MS/MS is widely used in biomarker analysis, contributing to advances in disease diagnosis, drug development, and personalized medicine. By accurately identifying and quantifying specific proteins or peptides, MS/MS enables the discovery of novel biomarkers and provides insights into disease mechanisms.
One of the key applications of MS/MS in biomarker analysis is in the field of proteomics. By analyzing the protein composition of biological samples, researchers can identify disease-specific biomarkers, assess treatment response, and discover potential therapeutic targets.
MS/MS also facilitates the study of post-translational modifications (PTMs), which play critical roles in protein function and cellular processes.
MS/MS Services Offered by Creative BioMart Biomarker
As a leader in biomarker analysis, Creative BioMart Biomarker offers comprehensive MS/MS services to meet the specific needs of researchers and industry partners. Our state-of-the-art facilities, team of experienced scientists, and commitment to quality ensure accurate and reliable results.
- Biomarker discovery: We employ cutting-edge MS/MS techniques to identify novel biomarkers associated with various diseases. By utilizing high-resolution MS and advanced data analysis algorithms, we can discover potential biomarkers for early disease detection and prognosis.
- Biomarker Validation: Once potential biomarkers are identified, we conduct rigorous validation studies to assess their clinical utility. Our expertise in targeted MS/MS methods enables precise quantitation of biomarkers, ensuring reliable results from validation studies.
- PTM analysis: We specialize in post-translational modification analysis using MS/MS. Our advanced workflows and bioinformatics tools identify and quantify PTMs, revealing their functional significance in disease processes.
The Flow of MS/MS
Our Advantages
- Our knowledge and proficiency allow us to deliver accurate and reliable results.
- Equipped with advanced MS instrumentation and cutting-edge technology for high-throughput analysis, ensuring fast turnaround times without compromising quality.
- We adhere to strict quality control measures at every step of the analytical process to ensure the accuracy and reliability of the results.
- Work closely with clients to design custom MS/MS workflows to meet their requirements and deliver actionable insights.
Creative BioMart Biomarker provides comprehensive MS/MS services to researchers and industry partners. Contact us today to unlock the potential of MS/MS for your biomarker research needs.
Reference:
- Neagu, A.N.; et al. Applications of Tandem Mass Spectrometry (MS/MS) in Protein Analysis for Biomedical Research. Molecules. 2022, 27(8): 2411.
