Vitamin K Detection Service
Vitamin K exerts its anabolic effects on bone turnover in different ways, such as promoting the differentiation of osteoblasts, up-regulating the transcription of specific genes in osteoblasts, and activating the expression of bone-related vitamin K-dependent proteins, thus playing an important role in bone formation. Creative BioMart Biomarker is capable to provide our customers with superior vitamin K detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
Introduction
Bone is a metabolically active tissue that is renewed throughout life. Cytokines and several hormonal, nutritional and growth factors regulate bone remodeling. Vitamin K is a multifunctional vitamin that plays an important role in keeping bones strength. Vitamin K is a fat-soluble vitamin first identified in blood coagulation; “K” stands for "Koagulation", a Danish term for coagulation. Vitamin K has a wide range of biological activities, including regulation of calcium metabolism in tissues, cell growth and proliferation, oxidative stress, inflammatory response, blood coagulation and hemostasis. Vitamin K has a wide range of biological activities, including regulation of intracellular calcium metabolism, cell growth and proliferation, oxidative stress, inflammatory response, blood clotting and hemostasis. There are two types of Vitamin K: vitamin K1 and vitamin K2. Vitamin K1, also known as phylloquinone or phytonadione, is synthesized in plants and is the main form of vitamin K in the human diet. Vitamin K2 is a group of compounds with specific formulation that contain a naphthoquinone ring and side chains of varying lengths. The chemical formulation of Vitamin K2 is menaquinones-n (MK-n), and n refers to the number of isoprenoid chains. Different vitamin Ks have different biological activities due to differences in enzyme affinity and tissue distribution. Vitamin K1 is mainly stored in the liver and plays an important role in the production of blood coagulation proteins, while vitamin K2 is widely distributed in human body. Vitamin K2, particularly MK-4, promotes bone formation by stimulating osteoblast differentiation, regulating extracellular matrix mineralization, upregulating bone marker gene expression, and inhibiting osteoclastogenesis.
Figure 1. Metabolic pathways involved in vitamin K.
Application of vitamin K
- Plasma, serum vitamin K levels as biomarkers to predict bone formation.
Our Advantages
- Ensure high sensitivity for detecting vitamin K in different samples
- Ensure high accuracy and repeatable vitamin K detection
- Ensure a wide kinetic range to detect samples of different concentrations
- Short experimental period
Workflow of Vitamin K Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the vitamin K detection procedure to ensure high sensitivity, high accuracy and repeatable vitamin K detection.
Please feel free to contact us if you would like to know more about vitamin K detection. At Creative BioMart Biomarker, we not only provide high-quality vitamin K detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.
References:
- Akbari, S.; et al. Vitamin K and bone metabolism: a review of the latest evidence in preclinical studies. BioMed Research International. 2018, doi: 10.1155/2018/4629383.
- Hamidi, M.S.; et al. Vitamin K and bone health. Journal of Clinical Densitometry. 2013, 16(4):409-13.
