Transforming growth factor-β (TGF-β) is a pleiotropic cytokine involved in the regulation of various immune cells and plays a key role in the research of immune-related diseases. Creative BioMart Biomarker provides TGF-β testing services for clients engaged in disease research and basic research. Years of biomarker service experience enables us to provide customers with fast and accurate TGF-β testing services. Our services are not suitable for private medical diagnosis and testing.
TGF-β
Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that plays a key role in suppressing peripheral immune responses and preventing autoimmune responses. TGF-β has three isoforms with similar biological functions, namely TGF-β1, TGF-β2 and TGF-β3, of which TGF-β1 is mainly expressed in the immune system. The three isoforms of TGF-β are produced in the form of inactive complexes and must be activated to bind to the receptor. The TGF-β receptor complex is composed of TGF-βRI and TGF-βRII. TGF-β firstly binds to TGF-βRII, causing TGF-βRII to undergo conformational changes, so that TGF-βRII and TGF-βRI dimerize to form a tetrameric complex, which binds to active TGF-β to activate the downstream signal pathway. The TGF-β superfamily contains multiple members, in addition to TGF-β, it also contains activins, bone morphogenetic proteins, and growth differentiation factors. TGF-β participates in the regulation of cell proliferation, differentiation, migration and survival, and affects various biological processes including immune response and fibrosis. TGF-β can regulate the chemotaxis and activation of lymphocytes, dendritic cells, macrophages, granulocytes and other cells in the periphery, thereby regulating the initiation and regression of inflammatory responses. Regulating the immune response is particularly important for preventing the development of autoimmune diseases, and TGF-β, as a key immunosuppressive cytokine, plays a role in preventing the development of autoimmune diseases.
Figure 1. The TGF-β signaling pathway (Batlle, et al. 2019)
Application of TGF-β Detection
TGF-β levels can be used as biomarkers in researches related to rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), systemic lupus erythematosus (SLE), etc.
Our Advantages
- Guarantee high accuracy and sensitivity for TGF-β detection
- Ensure high repeatability of TGF-β detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, etc.
- Target species: human, mouse, rabbit, rat, porcine, canine, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality TGF-β detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Batlle, E.; Massagué, J. Transforming growth factor-β signaling in immunity and cancer. Immunity. 2019, 50(4): 924-940.
- Worthington, J.J.; et al. Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells. Immunobiology. 2012, 217(12): 1259-1265.
- Wrzesinski, S. H.; et al. Transforming growth factor-β and the immune response: implications for anticancer therapy. Clinical Cancer Research. 2007, 13(18): 5262-5270.
