Surface enhance laser desorption/ionization time-of-flight (SELDI-TOF) is an extremely sensitive technique that can accurately detect and measure the quantity of various biomolecules present in complex biological samples. Creative BioMart Biomarker has advanced technology and a professional team, and has been committed to promoting the development of the field of biomarker research. Our comprehensive SELDI-TOF services can provide valuable insights into biomarkers, paving the way for research and new treatments for a variety of diseases.
SELDI-TOF and Biomarker
SELDI is a variant of matrix-assisted laser desorption/ionization (MALDI). SELDI-TOF utilizes chips to capture target biomolecules from complex biological samples. A laser is fired at its co-crystallized mixture with the matrix material, which dissociates to produce charged ions that are then separated and detected by a time-of-flight mass spectrometer. The resulting spectra are finally analyzed to identify and quantify the biomolecules present in the sample.
SELDI-TOF is a very powerful biomarker identification and analysis tool that has been used for biomarker research in a range of diseases, including cancer, Alzheimer's disease, and cardiovascular disease. Identification of specific biomarkers by SELDI-TOF can facilitate early diagnosis of diseases, monitor disease progression and facilitate the development of personalized treatments.
Figure 1. Simplified overview of the SELDI process for diagnostic biomarker discovery (Ndao, M.; et al. 2010)
SELDI-TOF Services
Our range of SELDI-TOF services for biomarker analysis is broad and diverse, including protein profiling, comparative analysis, and biomarker discovery.
- Protein profiling involves the careful examination of complex protein mixtures to identify and quantify specific proteins of interest.
- Comparative analysis aims to compare protein profiles of different samples to identify differences or similarities that may be indicative of disease or other biological processes.
- With SELDI-TOF technology, by analyzing the protein profiles of diseased and healthy tissues, researchers can identify proteins uniquely expressed in diseased tissues and use them as biomarkers for early detection, diagnosis and monitoring of disease progression.
Our SELDI-TOF services for biomarker analysis provide comprehensive services, from sample preparation to SELDI-TOF and data analysis. We also provide customized services based on the specific needs of our clients, including biomarker discovery and validation.
Our Advantages
- Our experienced team of researchers and technicians are highly skilled in utilizing cutting-edge equipment and latest technologies to provide clients with accurate and reliable results.
- Excellent customer service and a commitment to satisfy customers' needs in every possible way.
- Work closely with clients to develop custom experimental designs and protocols to meet their specific research needs.
- Competitive price and short service cycle.
Workflow of SELDI-TOF Services
Creative BioMart Biomarker provides customers with a wide range of SELDI-TOF services to facilitate biomarker-related research. Our team can provide customized services to meet the needs of different studies. If you would like to learn more about our services and how they can help you with your research, please feel free to contact us.
Reference:
- Ndao, M., et al. Is SELDI-TOF a valid tool for diagnostic biomarkers? Trends Parasitol. 2010, 26(12): 561-567.
