Pre-β1 HDL Detection Service
Pre-β1 HDL is a subgroup of high density lipoprotein (HDL) that is the first receptor for cellular free cholesterol and functions in the reverse cholesterol transport. The concentration of plasma pre-β1 HDL can be used as a risk marker for cardiovascular disease. Creative BioMart Biomarker is capable to provide our customers with superior pre-β1 HDL detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
Introduction
HDL is highly heterogeneous and differs in size, structure and composition. HDL is divided into two major subpopulations, one subgroup with α-mobility and the other subgroup with a similar migration to very low density lipoprotein (VLDL), called pre-β HDL. Most of the HDL in plasma is α HDL, and pre-β HDL accounts for only 2-14% of apolipoprotein A-I. Pre-β HDL has three small branches according to its size: pre-β1, pre-β2 and pre-β3 HDL. Among them, pre-β1 HDL is the first receptor for cellular free cholesterol. Studies have shown that HDL has multiple anti-atherosclerotic protective functions, and various HDL subpopulations have different anti-atherosclerotic properties. Pre-β1 HDL is a special subpopulation of HDL whose main components are apolipoprotein A1 and phospholipids. The interaction of Pre-β HDL with ATP-binding cassette transporter A1 (ABCA1) promotes cellular cholesterol efflux, while pre-β1 HDL plays an important role in the reverse cholesterol transport. It obtains free cholesterol through ABCA1 and then esterifies cholesterol through lecithin-cholesterol acyltransferase (LCAT) to form large diameter HDL particles with α-mobility. Pre-β1 HDL aggregates into one particle when HDL is formed. Cholesteryl ester transporter protein (CETP) transfers cholesteryl esters from HDL to receptor lipoproteins and ultimately to the liver. The pre-β1 HDL is regenerated in this process. And studies have shown that pre-β1 HDL can be used as a risk marker for cardiovascular disease. The absolute level of pre-β1 HDL can be used as an indicator of structural coronary artery disease and myocardial infarction, and also for carotid disease.
Application of Pre-β1 HDL
Plasma level of pre-β1 HDL can be used as a biomarker predicts the risk of cardiovascular disease such as structural coronary artery disease, myocardial infarction and also for carotid disease.
Our Advantages
- Accept a wide range of sample types
- Provide multiple detection methods
- Ensure high sensitivity for detecting pre-β1 HDL in different samples
- Ensure high accuracy and repeatable pre-β1 HDL detection
- Ensure a wide kinetic range to detect samples of different concentrations
- Short experimental period
Workflow of Pre-β1 HDL Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the pre-β1 HDL detection procedure to ensure high sensitivity, high accuracy and repeatable pre-β1 HDL detection.
Please feel free to contact us if you would like to know more about pre-β1 HDL detection. At Creative BioMart Biomarker, we not only provide high-quality pre-β1 HDL detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.
References:
- Barrans, A.; et al. Pre-β HDL: structure and metabolism. Biochim Biophys Acta.1996, 1300(2): 73-85.
- Shiu, S.W; et al. Pre-β1 HDL in type 2 diabetes mellitus. Atherosclerosis. 2017, 263: 24-28.
- Kane, J.P.; Malloy, M.J. Prebeta-1 HDL and coronary heart disease. Curr Opin Lipidol. 2012, 23(4): 367-71.
