P-selectin is a member of the selectin family. It can be used as a biomarker of platelet activation and also used as a biomarker in basic research on adverse cardiovascular events and inflammatory diseases. Creative BioMart Biomarker is capable to provide our customers with superior P-selectin testing service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
P-selectin is also known as granule membrane protein 140 (GMP-140) and platelet activation dependent granule external membrane protein (PADGEM). P-selectin is expressed by circulating platelets and endothelial cells. It is not only a component of the membrane of the alpha and dense granules of platelets, but also a component of the membrane of the Weibel–Palade bodies of endothelial cells. P-selectin is a 140kDa adhesion molecule, the largest one in the selectin family. Selectin is a single-chain transmembrane glycoprotein that can be expressed on endothelial cells, leukocytes and platelets, and has similar properties to C-type lectins. The selectin family has similar domains, including C-type lectin domain, epidermal growth factor-like domain, short consensus repeats (the number of repeat units in P-selectin is 9), a transmembrane region and a cytoplasmic domain. Selectins can regulate leukocyte recruitment and play an important role in inflammation. After the stimulation of inflammatory mediators, the expression level of P-selectin on endothelial cells was rapidly increased. At the same time, P-selectin can also be used as a biomarker of platelet activation. P-selectin mediates platelet rolling in inflammation, and its expression on activated platelets contributes to the adhesion of leukocytes and the formation of platelet aggregates. P-selectin regulates the interaction between blood cells and endothelium, and its soluble form can be used as a plasma predictor of adverse cardiovascular events.
Figure 1. P-selectin and its ligands (Perkins, et al. 2019)
P-selectin levels can be used as biomarkers in researches related to systemic inflammatory response syndrome (SIRS), vascular injury, cervicovaginal inflammation, inflammatory bowel disease (IBD), etc.
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of P-selectin in each sample.
At Creative BioMart Biomarker, we offer high-quality P-selectin detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.