Creative BioMart Biomarker provides neuron-specific enolase (NSE) testing outsourcing services for scientists in the field of biomarkers or disease researches, and we always offer service results with accuracy, specificity and repeatability.
Our testing services are only suitable for scientific research, not intended for clinical diagnosis and testing.
|
NSE Testing |
| Analyte: |
NSE |
| Synonyms: |
neuron-specific enolase, γ-enolase or enolase-2, ENO2 |
| Sample Type: |
plasma, serum or other biological fluids |
| Assay Platform: |
ELISA |
| Biomarker Application Area: |
small cell lung cancer (SCLC), non-small cell lung cancer, Merkel cell carcinoma, neuroendocrine tumors, neuroblastoma, etc. |
| * Perform three replicate tests on each sample, and include appropriate controls in each assay. |
Assay Background
Figure 1. Space conformation of NSE (Xu, et al. 2019)
NSE is one of the three isozymes of enolase, mainly located in central and peripheral neurons and neuroendocrine cells. Enolase may play a leading role in inflammatory metabolism and promote tumor proliferation under hypoxic conditions by enhancing glycolysis. Due to its localization characteristics, NSE is often used as a potential biomarker for neuronal death in central nervous system injury. In addition to this, it also has multiple functions in cancer progression. For example, NSE can promote cancer cell survival and proliferation by enhancing aerobic glycolysis. In cancer, the cell positioning of NSE can change and traffic to the cell surface to promote the migration of tumor cells by activating signaling pathways. The expression level of NSE is increased in a variety of cancers. NSE is considered to be a reliable biomarker for SCLC, and its expression level in serum is correlated with tumor size, disease stage, and tumor metastasis. NSE has high specificity for SCLC, and the detection of serum NSE helps to improve the early diagnosis efficiency of SCLC, and also has application prospects in disease monitoring and prognosis analysis.
Why Choose Creative BioMart Biomarker for NSE Detection Service?
- High-quality ELISA technology platform
Over the years, our expert team has spent a lot of energy to establish a high-quality ELISA technology platform, and select ELISA kits with high sensitivity and specificity for testing to meet the experimental needs of customers.
- Experienced experts team
We have many experts with rich experience in biomarker testing. They always treat each test with a rigorous attitude and can always provide customers with accurate, precise and repeatable test results.
- Suitable for multiple sample types
Our biomarker testing service is applicable to several sample types, including serum, plasma, etc. If your sample type is not common, you can contact us at any time to inquire about the testing service for your sample type.
- Fast testing and reasonable price
We have been committed to providing customers with efficient services to ensure that the experimental results are delivered within the predetermined time. Our testing services have reasonable and competitive prices in the industry, which can help customers reduce research costs.
If you are interested in our services, please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Boyd, M. T.; Vlatkovic, N. P53: a molecular marker for the detection of cancer. Expert Opinion on Medical Diagnostics. 2008, 2(9): 1013-1024.
- Urso, L.; et al. Critical review about MDM2 in cancer: possible role in malignant mesothelioma and implications for treatment. Critical Reviews in Oncology/Hematology. 2015, 97(8428): 220-230.
- Xu, C. M.; et al. Multifunctional neuron-specific enolase: its role in lung diseases. Bioscience Reports. 2019. 39(11): BSR20192732.
