IL-6 is a pleiotropic cytokine with multiple biological activities, which is involved not only in inflammation but also in the regulation of cardiac metabolism. Elevated levels of circulating and intracardiac IL-6 have been detected in a variety of cardiovascular diseases, so IL-6 has potential as a biomarker for cardiovascular disease. Creative BioMart Biomarker is capable to provide our customers with superior IL-6 detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
Introduction
IL-6 is a pleiotropic cytokine with multiple biological activities, including stimulating B cell differentiation, activating thymocyte and T cell differentiation, activating macrophages, stimulating liver cells to produce acute phase proteins, and activating NK cells. IL-6 has pro-inflammatory and anti-inflammatory properties. It is produced not only by immune cells and immune accessory cells, but also by cardiovascular components such as endothelial cells, vascular smooth muscle cells, and ischemic myocytes. IL-6 is unique in that it is not only involved in inflammation, but also in the regulation of cardiac metabolism.
According to reports, in patients with congestive heart failure (CHF), circulation and intracardiac IL-6 levels are increased. IL-6 may cause myocardial damage and dysfunction in chronic heart failure syndrome caused by different causes. As a cause of CHF in cardiomyopathy, myocarditis, allograft rejection, and left ventricular assist device (LVAD) conditions, circulating IL-6 levels correlate with the severity of left ventricular dysfunction and are powerful for subsequent clinical results indicators. In viral myocarditis, continuous and excessive IL-6 production disrupts the cytokine network and virus clearance, thereby promoting myocardial injury. IL-6 can cause cardiac hypertrophy through IL-6 signal transduction receptor component glycoprotein 130.
Application of IL-6
Plasma levels of IL-6, can be used as a potential biomarker for cardiovascular disease.
Our Advantages
- Accept a wide range of sample types
- Provide multiple detection methods
- Ensure high sensitivity for detecting IL-6 in different samples
- Ensure high accuracy and repeatable IL-6 detection
- Ensure a wide kinetic range to detect samples of different concentrations
- Short experimental period
Workflow of IL-6 Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the IL-6 detection procedure to ensure high sensitivity, high accuracy and repeatable IL-6 detection.
Please feel free to contact us if you would like to know more about IL-6 detection. At Creative BioMart Biomarker, we not only provide high-quality IL-6 detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.
References:
- Kanda, T.; Takahashi, T. Interleukin-6 and cardiovascular diseases. Jpn Heart J. 2004, 45(2): 183-93.
