IL-2Rα Detection Service

Interleukin (IL) -2 and IL-2 receptor (IL-2R) signaling plays an important role in regulating tolerance and immunity. IL-2R is a trimer receptor that contains three subunits, IL- 2Rα, IL-2Rβ and IL-2γc. Increased plasma sIL-2Rα levels are associated with a variety of diseases, including autoimmune diseases, rheumatoid arthritis, and cardiovascular diseases. Creative BioMartBiomarker is capable to provide our customers with superior IL-2Rα detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.


IL -2 and IL-2R signaling plays an important role in regulating tolerance and immunity. IL-2 is a T cell growth factor that induces antigen-activated T cell proliferation and differentiation, and is particularly important for the development of regulatory T cells in the thymus. IL-2R is a trimer receptor that contains three subunits: IL-2Rα (CD25), IL-2Rβ (CD122), and IL-2γc (CD132). IL-2Rα is specific for IL-2R, while IL-2Rβ and IL-2γc are components shared by other cytokine receptors. Soluble IL-2Rα (sIL-2Rα) is produced by proteolytic cleavage of IL-2Rα on the cell surface caused by membrane metalloproteinases (extracellular domain shedding). Since sIL-2Rα has similar IL-2 binding kinetics to the membrane form, sIL-2Rα can reduce the immune response by binding and isolating IL-2.

The IL-2 receptor.Figure 1. The IL-2 receptor.

Elevated plasma sIL-2Rα levels are associated with autoimmune diseases, including Crohn disease, rheumatoid arthritis, and multiple sclerosis. Higher levels of sIL-2Rα are observed in patients with coronary heart disease. In mouse models, IL-2 increases the number of regulatory T cells in atherosclerotic plaques and reduces the size of these plaques. When IL-2R is blocked in these models, the plaque reduction is negated. Subsequent research found that sIL-2Rα was positively associated with smoking, type 2 diabetes, hypertension, insulin, waist circumference, C-reactive protein, IL-6, fibrinogen, carotid wall thickness, all-cause mortality, CVD mortality and CVD, stroke, and heart failure.

Application of IL-2Rα

Plasma levels of IL-2Rα, can be used as a potential biomarker for cardiovascular disease.

Our Advantages

  • Accept a wide range of sample types
  • Provide multiple detection methods
  • Ensure high sensitivity for detecting IL-2Rα in different samples
  • Ensure high accuracy and repeatable IL-2Rα detection
  • Ensure a wide kinetic range to detect samples of different concentrations
  • Short experimental period

Workflow of IL-2Rα Detection at Creative BioMart Biomarker

Creative BioMart Biomarker strictly controls each specific experimental step in the IL-2Rα detection procedure to ensure high sensitivity, high accuracy and repeatable IL-2Rα detection.


Please feel free to contact us if you would like to know more about IL-2Rα detection. At Creative BioMart Biomarker, we not only provide high-quality IL-2Rα detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.


  1. Durda, P.; et al. Plasma levels of sIL-2Rα: associations with clinical cardiovascular events and genome- wide association scan. Arterioscler Thromb Vasc Biol. 2015, 35(10): 2246–2253.
  2. Dembic, Z. Cytokines of the Immune System: Interleukins. The Cytokines of the Immune System. 2015, 143-239.


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