IL-1Ra Detection Service

Interleukin-1 (IL-1) was originally thought to be a lymphocyte activating factor, but it was later found to have multiple effects, including inducing inflammation, raising body temperature, raising body temperature, and stimulating T and B cell proliferation. The IL-1 mediated inflammatory response can be eliminated by the natural inhibitor IL-1 receptor antagonist (IL-1Ra). There is evidence that IL-1 is involved in the pathogenesis of certain cardiovascular diseases, and researchers have pointed out the role of IL-1Ra in the formation of atherosclerosis. Creative BioMartBiomarker is capable to provide our customers with superior IL-1Ra detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.


IL-1 is the term for two different but related proteins, namely IL-1α and IL-1β, encoded by two separate genes. They produce a 31 kDa precursor under stress or cell injury and are subject to proteolysis by specific proteases during maturation. IL-1α and IL-1β use the same membrane receptor (IL-1R) to trigger signal transduction pathways, leading to the activation of NF-κB or AP-1. The IL-1 mediated inflammatory response can be eliminated by the natural inhibitor IL-1Ra. IL-1Ra binds to two IL-1 proteins in the IL-1 protein family. When IL-1Ra binds to IL-1R, it does not activate the signaling pathway.

The IL-1 signaling and its negative regulationFigure 1. The IL-1 signaling and its negative regulation.

Other researchers have pointed out the role of IL-1Ra in the formation of atherosclerosis, and the lack of IL-1Ra has obvious potential for promoting atherosclerosis. In addition, studies have found that systemic IL-1Ra levels are elevated in individuals with cardiac metabolic risk factors such as obesity, insulin resistance, and type 2 diabetes. Further research found that serum IL-1Ra levels were positively correlated with the risk of cardiovascular disease.

Application of IL-1Ra

Serum levels of IL-1Ra, can be used as a biomarker of the risk of cardiovascular disease.

Our Advantages

  • Accept a wide range of sample types
  • Provide multiple detection methods
  • Ensure high sensitivity for detecting IL-1/IL-Ra in different samples
  • Ensure high accuracy and repeatable IL-1/IL-Ra detection
  • Ensure a wide kinetic range to detect samples of different concentrations
  • Short experimental period

Workflow of IL-1Ra Detection at Creative BioMart Biomarker

Creative BioMart Biomarker strictly controls each specific experimental step in the IL-1Ra detection procedure to ensure high sensitivity, high accuracy and repeatable IL-1Ra detection.


Please feel free to contact us if you would like to know more about IL-1Ra detection. At Creative BioMart Biomarker, we not only provide high-quality IL-1Ra detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.


  1. Vicenová, B.; et al. Emerging role of interleukin-1 in cardiovascular diseases. Physiol. Res. 2009, 58: 481-498.
  2. Herder, C.; et al. Circulating levels of interleukin 1-receptor antagonist and risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2017, 37: 1222-1227.


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