Interleukin-1 (IL-1) was originally thought to be a lymphocyte activating factor, but it was later found to have multiple effects, including inducing inflammation, raising body temperature, raising body temperature, and stimulating T and B cell proliferation. The IL-1 mediated inflammatory response can be eliminated by the natural inhibitor IL-1 receptor antagonist (IL-1Ra). There is evidence that IL-1 is involved in the pathogenesis of certain cardiovascular diseases, and researchers have pointed out the role of IL-1Ra in the formation of atherosclerosis. Creative BioMartBiomarker is capable to provide our customers with superior IL-1Ra detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
Introduction
IL-1 is the term for two different but related proteins, namely IL-1α and IL-1β, encoded by two separate genes. They produce a 31 kDa precursor under stress or cell injury and are subject to proteolysis by specific proteases during maturation. IL-1α and IL-1β use the same membrane receptor (IL-1R) to trigger signal transduction pathways, leading to the activation of NF-κB or AP-1. The IL-1 mediated inflammatory response can be eliminated by the natural inhibitor IL-1Ra. IL-1Ra binds to two IL-1 proteins in the IL-1 protein family. When IL-1Ra binds to IL-1R, it does not activate the signaling pathway.
Figure 1. The IL-1 signaling and its negative regulation.
Other researchers have pointed out the role of IL-1Ra in the formation of atherosclerosis, and the lack of IL-1Ra has obvious potential for promoting atherosclerosis. In addition, studies have found that systemic IL-1Ra levels are elevated in individuals with cardiac metabolic risk factors such as obesity, insulin resistance, and type 2 diabetes. Further research found that serum IL-1Ra levels were positively correlated with the risk of cardiovascular disease.
Application of IL-1Ra
Serum levels of IL-1Ra, can be used as a biomarker of the risk of cardiovascular disease.
Our Advantages
- Accept a wide range of sample types
- Provide multiple detection methods
- Ensure high sensitivity for detecting IL-1/IL-Ra in different samples
- Ensure high accuracy and repeatable IL-1/IL-Ra detection
- Ensure a wide kinetic range to detect samples of different concentrations
- Short experimental period
Workflow of IL-1Ra Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the IL-1Ra detection procedure to ensure high sensitivity, high accuracy and repeatable IL-1Ra detection.
Please feel free to contact us if you would like to know more about IL-1Ra detection. At Creative BioMart Biomarker, we not only provide high-quality IL-1Ra detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.
References:
- Vicenová, B.; et al. Emerging role of interleukin-1 in cardiovascular diseases. Physiol. Res. 2009, 58: 481-498.
- Herder, C.; et al. Circulating levels of interleukin 1-receptor antagonist and risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2017, 37: 1222-1227.
