Interleukin 18 (IL-18) is a factor that plays a key role in inflammation and immune response. It is related to many autoimmune diseases and is one of the research targets of these diseases. Creative BioMart Biomarker provides scientists with fast and sensitive IL-18 detection services. The professional team and rich experience can provide customers with reliable detection results and help customers accelerate research progress.
IL-18
IL-18 is a protein expressed in many types of cells. It was originally discovered and described as an interferon-γ-inducing factor due to its important role in inflammation and immune response. IL-18 is a member of the IL-1 family. The IL-1 family initially contained only IL-1α and IL-1β, and later expanded to a family of 11 members (IL-1α, IL-1β, IL-1Ra, IL-18, IL-36α, IL-36β, IL-36Ra, IL-37, IL-36γ, IL-38, IL-33). There is a correlation between IL-18 and IL-1 β, they are first synthesized as inactive precursors, and both of them need caspase-1 and protease-3 for cleavage and extracellular processing, respectively. In addition, IL-18 and IL-1 α also have similarities, and their precursors are both present in mesenchymal cells and related to monocyte membranes. IL-18 works by binding to its receptor. The IL-18 receptor can bind to IL-37. The IL-18 precursor and IL-37 precursor have a closely related tertiary structure, and their gene structure also suggests the correlation between the two. IL-18 can induce T cells to produce IFN-γ, which requires the processing of caspase-1. The main immunomodulatory effect of IL-18 is reflected in NK cells. IL-18 is associated with a variety of diseases, including autoimmune diseases, metabolic syndrome, macrophage activation syndrome and sepsis, etc., and the production of IL-18 is increased in several autoimmune diseases. IL-18 may also be related to some clinical manifestations related to caspase-1 activation in inflammatory diseases. Therefore, IL-18 is currently an important target in the research of some immune diseases and inflammatory diseases.
Figure 1. IL-18 in Innate and Adaptive Immunity (Garlanda, et al. 2013)
Application of IL-18 Detection
IL-18 levels can be used as biomarkers in researches related to autoimmune diseases, metabolic syndrome, macrophage activation syndrome, sepsis, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for IL-18 detection
- Ensure high repeatability of IL-18 detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, etc.
- Target species: human, mouse, rat, porcine, bovine, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality IL-18 detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Garlanda, C.; et al. The interleukin-1 family: back to the future. Immunity. 2013, 39(6): 1003-1018.
- Dinarello, C. A. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunological Reviews. 2018, 281(1): 8-27.
