Interleukin 17 (IL-17) is a key cytokine in the human body, and the signal transduction mechanism mediated by it is of great significance for the research of various immune diseases. Creative BioMart Biomarker provides testing services for IL-17A, IL-17B, IL-17F, etc. Our testing services are not suitable for private medical diagnosis and testing. Our efficient testing services with reasonable and competitive testing prices can help researchers shorten the research cycle and reduce research costs.
IL-17
IL-17 is a cytokine originally isolated from murine T-cell hybridomas. In the early stage, it was considered to be a subtype of the cytotoxic T lymphocyte-associated protein (CTLA) family, so it was called CTLA-8. It was later renamed IL-17. IL-17 has six homologous molecules, namely IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. Among them, IL-17A and IL-17F have a high degree of homology and have similar functions. IL-17A can be produced by several types of immune cells including T helper 17 cell. The receptor family of IL-17 has 5 members, including IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE. The 5 receptors have sequence homology, and their shared structures include the fibronectin III-like domain in the extracellular region and the SEF/IL-17R (SEFIR) domain in the intracellular region. IL-17RA is the shared receptor of IL-17 family cytokines, and IL-17RB, IL-17RC and IL-17RE are the specific receptors of IL-17E, IL-17A, IL-17F and IL-17C, respectively. IL-17RD is involved in the regulation of IL-17A signal transduction. IL-17A and IL-17F can induce pro-inflammatory gene expression alone or in conjunction with TNFα, IL-6, G-CSF, IL-1, CXCL, CCL20 and matrix metalloproteinases. IL-17 can also upregulate pro-inflammatory genes by activating NF-κB, MAPK and C/EBP cascades. In addition, IL-17 can activate the Jak-Stat and Jak-PI3 K pathways. The protein Act1 is also closely related to the functional pathway of IL-17. Act1 can serve as an anchoring platform at the proximal end of the receptor to initiate a TRAF6-dependent signaling pathway and a TRAF2-TRAF5-dependent cascade activated by IL-17.
Figure 1. Interleukin-17 Receptor Signaling (Zenobia, et al. 2015)
Application of IL-17 Detection
IL-17 levels can be used as biomarkers in researches related to rheumatoid arthritis, cancer, multiple sclerosis, chronic inflammatory bowel disease, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for IL-17 detection
- Ensure high repeatability of IL-17 detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, etc.
- Target species: human, mouse, rabbit, rat, porcine, canine, monkey, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality IL-17 detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Kuwabara, T.; et al. The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators of Inflammation. 2017, 2017: 3908061.
- Zenobia, C.; Hajishengallis, G. Basic biology and role of interleukin‐17 in immunity and inflammation. Periodontology. 2015, 69(1): 142-159.
