Interleukin-10 (IL-10) is a pleiotropic cytokine with important immune regulation functions, and is often an important target in the researches of immune diseases and immune responses. As a leader in biomarker services, Creative BioMart Biomarker provides efficient, accurate and reliable IL-10 testing services for scientists both in academia and industry, and has been committed to helping customers shorten research cycles and reduce research costs.
IL-10
IL-10 is also known as human cytokine synthesis inhibitory factor (CSIF), which is a pleiotropic, immunoregulatory cytokine encoded by the IL10 gene. IL-10 is mainly produced by B cells, macrophages, dendritic cells (DC), CD4+ and CD8+ T cells. It is a homodimer formed by the combination of two subunits each composed of 178 amino acids. During infection, IL-10 can affect the activity of many types of cells in the immune system. IL-10 can mediate its effects on T cells and natural killer (NK) cells functions through its direct effects on monocytes and macrophages. In addition, IL-10 can reduce the expression of MHC class II molecules on the surface of DCs and macrophages, weakening the function of antigen-presenting cells (APCs). It can also reduce the expression of proinflammatory cytokines and chemokines, thereby reducing the inflammatory response. IL-10 in CD4+ T cells can inhibit the production and proliferation of cytokines such as IFN-γ and TNF-α, so it can directly regulate Th1 and Th2 responses by inhibiting T cell activity and differentiation. IL-10 participates in the regulation of JAK-STAT signal transduction pathway through its receptor IL-10 receptor-1 and IL-10 receptor-2, thereby exerting its biological functions. IL-10 can protect the host from infection-related immunopathology. In patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and multiple sclerosis (MS), IL-10 has abnormal serum levels, and the imbalance of IL-10 expression in patients may play an important role in these diseases.
Figure 1. The sources and targets of IL-10 during infection (Couper, et al. 2008)
Application of IL-10 Detection
IL-10 levels can be used as biomarkers in researches related to SLE, MS, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for IL-10 detection
- Ensure high repeatability of IL-10 detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, etc.
- Target species: human, mouse, rabbit, rat, bovine, canine, chicken, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality IL-10 detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Couper, K. N.; et al. IL-10: the master regulator of immunity to infection. The Journal of Immunology. 2008, 180(9): 5771-5777.
- Ng, T. H. S.; et al. Regulation of adaptive immunity; the role of interleukin-10. Frontiers in Immunology. 2013, 4: 129.
