IL-1 Ra Detection Service
Interleukin 1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of interleukin 1 (IL1) activity, which has the effect of inhibiting inflammation. Creative BioMart Biomarker provides sensitive and accurate IL-1Ra detection services for scientists both in academia and industry. Efficient and reliable testing services, and reasonable and preferential prices can help customers accelerate the progress of related research.
IL-1 Ra
IL-1Ra is a glycosylated protein composed of 152 amino acids and is a member of the IL1 family. The IL-1 family initially contained only IL-1α and IL-1β, and later expanded into a family containing 11 members (IL-1α, IL-1β, IL-1Ra, IL-18, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37, IL-38, IL-33). IL-1 was originally thought to be a lymphocyte activating factor, but it was later found to have multiple effects, including inducing inflammation, raising the body temperature, and stimulating T and B cell proliferation. IL-1α and IL-1β produce a 31 kDa precursor under stress or cell injury and are subject to proteolysis by specific proteases during maturation. IL-1α and IL-1β use the same membrane receptor (IL-1R) to trigger signal transduction pathways, leading to the activation of NF-κB or AP-1. The IL-1 mediated inflammatory response can be eliminated by the natural inhibitor IL-1Ra. IL-1Ra binds to two IL-1 proteins in the IL-1 protein family. When IL-1Ra binds to IL-1R, it does not activate the signaling pathway and can specifically inhibit the activities of IL-1α and IL-1β. Therefore, naturally occurring IL-1Ra has an important effect on the human body, and its lack or low concentration is related to spontaneous diseases and the severity of the diseases, such as type 2 diabetes, destructive arthritis, etc. Researchers have conducted research on the recombinant form of IL-1Ra (Anakinra) for the treatment of rheumatoid arthritis, cryopyrin-associated periodic syndrome (CAPS), autoimmune hearing loss, pre-multiple myeloma, macrophage activation syndrome (MAS), etc.
Figure 1. Negative regulators of the IL-1 family (Garlanda, et al. 2013)
Application of IL-1 Ra Detection
IL-1 Ra levels can be used as biomarkers in researches related to type 2 diabetes, rheumatoid arthritis, CAPS, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for IL-1 Ra detection
- Ensure high repeatability of IL-1 Ra detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, etc.
- Target species: human, mouse, rabbit, rat, bovine, canine, chicken, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality IL-1 Ra detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Vicenová, B.; et al. Emerging role of interleukin-1 in cardiovascular diseases. Physiol. Res. 2009, 58: 481-498.
- Herder, C.; et al. Circulating levels of interleukin 1-receptor antagonist and risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2017, 37: 1222-1227.
- Garlanda, C.; et al. The interleukin-1 family: back to the future. Immunity. 2013, 39(6): 1003-1018.
