IL-1/IL-1Ra Ratio Detection Service

Interleukin-1 (IL-1) was originally thought to be a lymphocyte activating factor, but it was later found to have multiple effects, including inducing inflammation, raising body temperature, and stimulating T and B cell proliferation. Its activity is not limited to the immune system. IL-1 is also involved in regulating blood calcium levels, stimulating various body temperatures, regulating blood pressure or modulating sleeping. There is evidence that IL-1 is involved in the pathogenesis of certain cardiovascular diseases. Creative BioMartBiomarker is capable to provide our customers with superior IL-1/IL-1Ra Ratio detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.


IL-1 is the term for two different but related proteins, namely IL-1α and IL-1β, encoded by two separate genes. They produce a 31 kDa precursor under stress or cell injury and are subject to proteolysis by specific proteases during maturation. IL-1α and IL-1β use the same membrane receptor (IL-1R) to trigger signal transduction pathways, leading to the activation of NF-κB or AP-1. The IL-1 mediated inflammatory response can be eliminated by the natural inhibitor IL-1 receptor antagonist (IL-1Ra). IL-1Ra binds to two IL-1 proteins in the IL-1 protein family. When IL-1Ra binds to IL-1R, it does not activate the signaling pathway.

The IL-1 signaling and its negative regulationFigure 1. The IL-1 signaling and its negative regulation.

During the occurrence of atherosclerosis, IL-1 can up-regulate the expression of matrix metalloproteinases at plaque-forming sites. Matrix metalloproteinases can induce the breakdown of collagen in atheromatous plaques, causing atheromatous plaques instable and may cause thrombosis. Elevated levels of IL-1, TNF and IL-8 were found in atherosclerotic plaques, suggesting that IL-1 has proatherogenic properties. Other researchers have pointed out the role of IL-1Ra in the formation of atherosclerosis. The lack of IL-1Ra has obvious potential for promoting atherosclerosis. Therefore, the ratio of IL-1/IL-1Ra in plays an important role in the pathogenesis of vascular inflammation and atherosclerosis.

Application of IL-1/IL-1Ra Ratio

Serum levels of IL-1/IL-1Ra, can be used as a biomarker of atherosclerosis.

Our Advantages

  • Accept a wide range of sample types
  • Provide multiple detection methods
  • Ensure high sensitivity for detecting IL-1/IL-1Ra Ratio in different samples
  • Ensure high accuracy and repeatable IL-1/IL-1Ra Ratio detection
  • Ensure a wide kinetic range to detect samples of different concentrations
  • Short experimental period

Workflow of IL-1/IL-1Ra Ratio Detection at Creative BioMart Biomarker

Creative BioMart Biomarker strictly controls each specific experimental step in the IL-1/IL-1Ra Ratio detection procedure to ensure high sensitivity, high accuracy and repeatable IL-1/IL-1Ra Ratio detection.


Please feel free to contact us if you would like to know more about IL-1/IL-1Ra Ratio detection. At Creative BioMart Biomarker, we not only provide high-quality IL-1/IL-1Ra Ratio detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.


  1. Vicenová, B.; et al. Emerging role of interleukin-1 in cardiovascular diseases. Physiol. Res. 2009, 58: 481-498.


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