Interleukin-1 (IL-1) was originally thought to be a lymphocyte activating factor, but it was later found to have multiple effects, including inducing inflammation, raising body temperature, and stimulating T and B cell proliferation. Its activity is not limited to the immune system. IL-1 is also involved in regulating blood calcium levels, stimulating various body temperatures, regulating blood pressure or modulating sleeping. There is evidence that IL-1 is involved in the pathogenesis of certain cardiovascular diseases. Creative BioMartBiomarker is capable to provide our customers with superior IL-1/IL-1Ra Ratio detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
IL-1 is the term for two different but related proteins, namely IL-1α and IL-1β, encoded by two separate genes. They produce a 31 kDa precursor under stress or cell injury and are subject to proteolysis by specific proteases during maturation. IL-1α and IL-1β use the same membrane receptor (IL-1R) to trigger signal transduction pathways, leading to the activation of NF-κB or AP-1. The IL-1 mediated inflammatory response can be eliminated by the natural inhibitor IL-1 receptor antagonist (IL-1Ra). IL-1Ra binds to two IL-1 proteins in the IL-1 protein family. When IL-1Ra binds to IL-1R, it does not activate the signaling pathway.
Figure 1. The IL-1 signaling and its negative regulation.
During the occurrence of atherosclerosis, IL-1 can up-regulate the expression of matrix metalloproteinases at plaque-forming sites. Matrix metalloproteinases can induce the breakdown of collagen in atheromatous plaques, causing atheromatous plaques instable and may cause thrombosis. Elevated levels of IL-1, TNF and IL-8 were found in atherosclerotic plaques, suggesting that IL-1 has proatherogenic properties. Other researchers have pointed out the role of IL-1Ra in the formation of atherosclerosis. The lack of IL-1Ra has obvious potential for promoting atherosclerosis. Therefore, the ratio of IL-1/IL-1Ra in plays an important role in the pathogenesis of vascular inflammation and atherosclerosis.
Serum levels of IL-1/IL-1Ra, can be used as a biomarker of atherosclerosis.
Creative BioMart Biomarker strictly controls each specific experimental step in the IL-1/IL-1Ra Ratio detection procedure to ensure high sensitivity, high accuracy and repeatable IL-1/IL-1Ra Ratio detection.
Please feel free to contact us if you would like to know more about IL-1/IL-1Ra Ratio detection. At Creative BioMart Biomarker, we not only provide high-quality IL-1/IL-1Ra Ratio detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.