Interferon (IFN)-γ is one of the most studied immune biomarkers. Creative BioMart Biomarker provides sensitive and reliable IFN-γ detection services for customers in related research fields. We have many years of experience in biomarker testing services, and efficient testing and accurate results can effectively help customers advance research progress.
IFN-γ
IFNs are pleiotropic cytokines with anti-tumor and immunomodulatory properties. IFNs can be classified according to genetic loci, sequence identity, cell of origin, distribution of receptors, etc. IFN-α and IFN-β constitute the human type I IFN family, and IFN-γ is the only member of the type II IFN family. IFN-γ is mainly secreted by activated lymphocytes, but also by B cells, natural killer (NK) T cells and professional antigen-presenting cells. It is a homodimer formed by the non-covalent bonding of two polypeptide subunits, and has undergone multiple N-glycosylation during the synthesis process, and finally formed a 50kDa molecule. The biological effects of IFN-γ are achieved by activating molecular signaling pathways in cells. The combination of IFN-γ and its receptors IFNγR1 and IFNγR2 can activate the JAN/STAT pathway, thereby regulating the transcription of hundreds of genes and mediating different biological responses. The pleiotropic functions of IFN-γ are mediated by apoptosis and cell cycle regulators, inflammatory signaling molecules, transcriptional activators, etc. IFN-γ mainly activates anti-cancer immunity by promoting the activity of immune-related cells (including macrophages, NK cells, dendritic cells, etc.). It can also inhibit the differentiation and function of regulatory T cells, Th2 and Th17. IFN-γ is a major participant in human systemic autoimmune responses, and abnormal expression of IFN-γ can be found in autoimmune diseases. At the same time, its cellular targets may have the application prospect of prediction and treatment in tumor.
Figure 1. Immunomodulatory effects of IFN-γ (Castro, et al. 2018)
Application of IFN-γ Detection
IFN-γ levels can be used as biomarkers in researches related to rheumatoid arthritis, systemic lupus erythematous, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for IFN-γ detection
- Ensure high repeatability of IFN-γ detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, tissue homogenates, cell culture supernatants, etc.
- Target species: human, mouse, rabbit, rat, bovine, canine, chicken, goat, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality IFN-γ detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Castro, F.; et al. Interferon-gamma at the crossroads of tumor immune surveillance or evasion. Frontiers in Immunology. 2018, 9: 847.
- Pollard, K. M.; et al. Interferon-γ and systemic autoimmunity. Discovery Medicine. 2013, 16(87): 123-131.
