Intercellular adhesion molecule-1 (ICAM-1) is an immune-related molecule, which has research value in a variety of immune-related diseases. Creative BioMart Biomarker provides customers with ICAM-1 ELISA and CLIA testing services. Our testing services are suitable for many different types of samples and can meet the needs of different researchers. Our ICAM-1 testing service is not suitable for private medical diagnosis and testing.
Intercellular Adhesion Molecule-1
ICAM-1 is a transmembrane glycoprotein with a size of about 100kDa and belongs to the immunoglobulin supergene family. ICAM-1 is expressed in leukocyte subsets, endothelial cells, fibroblasts, glial cells, epithelial cells, etc. The full-length isoform of ICAM-1 consists of five Ig domains, a transmembrane domain, and a short cytoplasmic tail containing multiple threonine residues, which can interact with actin cytoskeleton and the ezrin/radixin/moesin complex associated with the lipid rafts. Membrane-bound ICAM-1 plays an important role in lymphocyte activation, leukocyte trafficking and some other immune functions. ICAM-1 can bind to a variety of ligands, including LFA-1, Mac-1, fibrinogen, hyaluronan and major rhinoviruses. The circulating form of ICAM-1 in body fluids, namely soluble ICAM-1 (sICAM-1), is produced by the proteolytic cleavage and alternative splicing of membrane-bound ICAM-1. sICAM-1 can also interact with LFA-1 and Mac-1. sICAM-1 is often studied as a biomarker and modulator that can promote inflammation. Its serum level is generally low, but it will increase in many inflammation-related pathological processes. Therefore, in a variety of diseases, ICAM-1 can be considered as a biomarker related to disease progression and severity.
Figure 1. Schematic representation of ICAM-1 isoforms. (A) Full-length ICAM-1 isoform. (B) ICAM-1 full-length isoforms dimerize by interaction through the fourth Ig domains. (C) The six membrane ICAM-1 isoforms. (D) Under inflammatory conditions, the Ig domain 5 of the full-length isoform is truncated.
Application of ICAM-1 Detection
ICAM-1 levels can be used as biomarkers in researches related to cancer, atherosclerosis, bacterial sepsis, type 2 diabetes, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for ICAM-1 detection
- Ensure high repeatability of ICAM-1 detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, tissue homogenates, etc.
- Target species: human, mouse, rabbit, rat, canine, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality ICAM-1 detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Ramos, T.N.; et al. ICAM-1: isoforms and phenotypes. The Journal of Immunology. 2014, 192 (10): 4469-4474.
- Müller, N. The role of intercellular adhesion molecule-1 in the pathogenesis of psychiatric disorders. Front Pharmacol. 2019, 10: 1251.
