Creative BioMart Biomarker provides scientists in the field of biomarkers or disease researches with accurate, sensitive and specific human epidermal growth factor receptor 2 (HER2) detection services. Our HER2 testing service is only suitable for scientific research, not intended for clinical diagnosis and testing.
|
HER2 Testing |
| Analyte: |
HER2 |
| Synonyms: |
human epidermal growth factor receptor 2, ERBB2, receptor tyrosine-protein kinase erbB-2, Neu |
| Sample Type: |
plasma, serum, tissue homogenates or other biological fluids |
| Assay Platform: |
ELISA, ECL |
| Biomarker Application Area: |
breast cancer, ovarian cancer, endometrial cancer, etc. |
| * Perform three replicate tests on each sample, and include appropriate controls in each assay. |
Assay Background
HER2 is one of the members of the human epidermal growth factor receptor (HER) family. It is a transmembrane protein with tyrosine kinase activity, composed of three parts: extracellular domain, transmembrane domain and intracellular tyrosine kinase active domain. HER2 gene is one of the important proto-oncogenes. As a transmembrane protein, HER2 can combine with growth factors on the cell surface to activate downstream signaling and promote cell survival, proliferation, differentiation and angiogenesis. HER2 can form a dimer, and two HER2 monomers or HER2 with other members of HER family to form a homodimer or heterodimer of HER2. The combination of dimer and ligand promotes protein phosphorylation and further activates downstream signaling pathways, including mitogen-activated protein kinase (MAPK), phospholipase C γ, phosphoinositide 3-kinase (PI3K/Akt), signal transducer and activator of transcription (STAT) and protein kinase C (PKC) signaling pathways. HER2 is a prognostic indicator for clinical treatment monitoring and an important target for the selection of tumor-targeted therapeutic drugs. Especially in the research and treatment of breast cancer, HER2 is an important biomarker.
Workflow of Biomarker Detection Services at Creative BioMart Biomarker
Customers provide: samples, reagents/kits (reagents/kits can also be provided or purchased by our company).
We provide: remaining samples and reagents, complete experimental reports (including experimental raw data, experimental procedures, instrument and reagent information, and professional result analysis).
Test cycle: 10 working days or less.
Why Choose Creative BioMart Biomarker for HER2 Detection Service?
- High-quality technology platform
Creative BioMart Biomarker provides two technology platforms for HER2 testing, ECL and ELISA. For the detection of biomarkers, our experts have optimized the technology platform to improve the sensitivity and specificity of the detection.
- Experienced experts team
We have many experts with rich experience in biomarker testing. They always treat each test with a rigorous attitude and can always provide customers with accurate, precise and repeatable test results.
- Suitable for multiple sample types
Our biomarker testing service is applicable to several sample types, including serum, plasma, tissue homogenates, etc. If your sample type is not common, you can contact us at any time to inquire about the testing service for your sample type.
- Fast testing and reasonable price
We have been committed to providing customers with efficient services to ensure that the experimental results are delivered within the predetermined time. Our testing services have reasonable and competitive prices in the industry, which can help customers reduce research costs.
If you are interested in our services, please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
Reference:
- Inês de Paula Costa Monteiro.; et al. Targeting HER family in HER2-positive metastatic breast cancer: potential biomarkers and novel targeted therapies. Pharmacogenomic. 2015, 16(3): 257-271.
