HE4 is a biomarker commonly used in ovarian cancer related research. Creative BioMart Biomarker provides customers with fast and sensitive HE4 ELISA testing services. This test is only suitable for research use, not for personal medical and diagnostic use.
|
HE4 Testing |
| Analyte: |
HE4 |
| Synonyms: |
WAP four-disulfide core domain protein 2, human epididymis protein 4 |
| Sample Type: |
serum, plasma, cell culture supernatants or other biological fluids |
| Assay Platform: |
ELISA |
| Biomarker Application Area: |
ovarian cancer, testicular cancer |
| * Perform three replicate tests on each sample, and include appropriate controls in each assay. |
Assay Background
HE4, also known as WAP four-disulfide core domain protein 2, is a reliable biomarker for ovarian cancer other than CA-125. HE4 is a glycoprotein belonging to the whey acidic four-disulfide core protein family, and can be used as a diagnostic biomarker for malignant ovarian tumors. HE4 has two WAP domains. Generally, proteins containing WAP domains are small secreted molecules, secreted by pro-inflammatory cells, have serine protease inhibitory activity, and participate in natural defenses against microorganisms. High levels of HE4 mRNA can be detected in the lungs, kidneys, and trachea. In addition, its mRNA can also be detected in the prostate, breast, and endometrium, while HE4 expression is rarely detected in the ovary. In epithelial ovarian cancer, the expression of HE4 is up-regulated, so scientists believe that detecting the serum concentration of HE4 can help the diagnosis of ovarian cancer. CA-125 is a commonly used biomarker for ovarian cancer, but its sensitivity and specificity for ovarian cancer are not high. The detection of HE4 can supplement this, thereby significantly improving the sensitivity of CA-125.
Workflow of Biomarker Detection at Creative BioMart Biomarker
Customers provide: samples, reagents/kits (reagents/kits can also be provided or purchased by our company).
We provide: remaining samples and reagents, complete experimental reports (including experimental raw data, experimental procedures, instrument and reagent information, and professional result analysis).
Test cycle: 10 working days or less.
Why Choose Creative BioMart Biomarker for HE4 Detection Service?
- High-quality ELISA technology platform
Over the years, our expert team has spent a lot of energy to establish a high-quality ELISA technology platform, and select ELISA kits with high sensitivity and specificity for testing to meet the experimental needs of customers.
- Experienced experts team
Our experts have extensive experience in biomarker testing, and will perform each test in full accordance with standard experimental operating procedures to ensure that the test results delivered are accurate and repeatable.
- Suitable for multiple sample types
Our biomarker testing service is applicable to several sample types, including serum, plasma, cell culture supernatant, etc. If your sample type is not common, you can contact us at any time to inquire about the testing service for your sample.
- Fast testing and reasonable price
We have been committed to providing customers with efficient services to ensure that the experimental results are delivered within the predetermined time. Our testing services have reasonable and competitive prices in the industry, which can help customers reduce research costs.
If you are interested in our services, please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Dochez, V.; et al. Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review. Journal of Ovarian Research. 2019, 12(1): 28.
- Li, J.P.; et al. HE4 as a biomarker for ovarian and endometrial cancer management. Expert Review of Molecular Diagnostics. 2009, 9(6), 555-566.
