Glycated albumin is a protein commonly used to detect blood glucose levels, which is formed by the Maillard reaction of albumin. Glycated albumin is generally suitable for short- or medium-term assessment of blood glucose levels and is suitable for use as a biomarker in patients with type 2 diabetes to observe changes in mean blood glucose. Creative BioMart Biomarker offers sensitive and fast test service for glycated albumin, ensuring high detection accuracy, reproducibility and efficiency.
Glycated albumin is a polymer ketone amine formed by a non-enzymatic glycosylation reaction between glucose and albumin in serum. Albumin is a 66.7 kDa protein formed from a polypeptide chain containing 585 amino acids and 17 disulfide bonds. Albumin is the main protein in plasma, has a physiological function of maintaining pH and blood osmotic pressure, and it is also a strong oxidant and a transporter of various substances such as metabolites, ions, hormones and fatty acids. Albumin undergoes a non-enzymatic spontaneous glycosylation reaction, which is generally referred to as Maillard reaction. The first step in the reaction is the formation of an unstable reversible product, the Schiff base. The conformation of the Schiff base will then be rearranged to form a stable, irreversible ketamine, generally called the Amadori product. Glycosylation of glycated albumin occurs mainly at the lysine site. In serum, non-enzymatic glycosylation of proteins forms a series of ketamines, the main component of which is glycated albumin. In the advanced glycosylation stage, glycosylated proteins undergo oxidation and irreversible reactions, resulting in stable heterogeneous compounds called advanced glycation end products. Glycosylation of proteins depends on the extent and duration of hyperglycemia. Glycated albumin acts as the main fructosamine in serum and is not affected by other serum protein concentrations. Glycated albumin is a clinically used indicator for detecting blood glucose levels in humans. It can reflect the average blood glucose level in the past 3-4 weeks and is suitable for observing the changes in short- and medium-term blood glucose. Glycated albumin is more suitable as a biomarker for type 2 diabetes than glycated hemoglobin. In addition, glycated albumin is also suitable for monitoring average blood glucose changes in dialysis anemia, acute systemic disease, liver disease, and hypoglycemic drug adjustment period.
Figure 1. Frequently glycated and AGE-modified sites in human serum albumin (Vetter, 2015)
Plasma and serum glycated albumin levels can be studied as a biomarker in researches related to type 2 diabetes mellitus, inflammation, etc.
Creative BioMart Biomarker strictly controls each specific experimental step in the glycated albumin detection procedure to ensure accurately quantify the level of glycated albumin in each sample.
At Creative BioMart Biomarker, we offer quality glycated albumin testing service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.