Glucagon is a type of peptide hormone involved in glycometabolism and is produced by islet alpha cells. The main function of glucagon is to increase the glucose concentration and maintain the balance of glycometabolism. The abnormality of glucagon concentration is related to the imbalance of glycometabolism, and is also associated with some diseases related to glycometabolism, such as diabetes mellitus and pancreatic tumors. Glucagon can be used as a biomarker for these diseases, and may be used to reflect disease status and as a prognostic indicator. Creative BioMart Biomarker offers sensitive testing service for glucagon, ensuring high detection accuracy, reproducibility and efficiency.
Glucagon is formed by processing proglucagon in islet alpha cells. It is a peptide hormone composed of 29 amino acids and is generally formed under the catalysis of prohormone converting enzyme 2. The main function of glucagon is to regulate the balance of glycometabolism. When the glucose supply is insufficient, such as during fasting, stress, and exercise, glucagon can increase glucose content by stimulating hepatic glycogenolysis and hepatic gluconeogenesis. The level of glucagon changes when glycometabolism is imbalanced. For example, the secretion of glucagon in diabetic patients is imbalanced, and the fasting plasma glucagon levels of patients with type 1 diabetes and type 2 diabetes are higher than those of healthy people. In addition, abnormally elevated glucagon may also be related to pancreatic tumors. The regulation mechanism of glucagon is complicated and related to many factors, such as insulin, GLP and glucose. In addition to its involvement in glycometabolism, glucagon is also involved in lipid metabolism. It can reduce the synthesis of fatty acids in adipose tissue and liver, and promote lipolysis. In some cases, glucagon can promote energy production in some tissues, such as skeletal muscle, through the breakdown of fatty acids. Glucagon may suppress obesity and promote weight loss by suppressing appetite, regulating lipid metabolism, activating energy expenditure and thermogenesis. Glucagon is an important element involved in glycometabolism, and it is related to many disease states and can be used as a biomarker for detection and research.
Figure 1. Some controls of glucagon secretion (Geary, 2017)
Plasma and serum glucagon levels can be studied as a biomarker in researches related to diabetes mellitus, pancreatic cancer, etc.
Creative BioMart Biomarker strictly controls each specific experimental step in the glucagon detection procedure to ensure accurately quantify the level of glucagon in each sample.
At Creative BioMart Biomarker, we offer glucagon detection service which include several technical methods, you can communicate with our experts according to your research needs, and we will determine the final detection technical scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.