Glucagon-like peptide (GLP) refers to a class of peptide hormones produced by cleavage of glucagon and secreted by islet alpha cells and enteroendocrine L cell lines, mainly including GLP-1 and GLP-2. GLP is associated with diabetes, obesity, and a variety of intestinal diseases. Creative BioMart Biomarker offers high quality detection service both for GLP-1 and GLP-2, ensuring high detection accuracy, reproducibility and efficiency.
Introduction
GLP refers to a class of peptide hormones involved in glucose metabolism, which is produced by cleavage of glucagon. The precursor of proglucagon is preproglucagon, which is produced by its cleavage. Preproglucagon in the human body is encoded by the GCG gene. Preproglucagon includes a signal peptide, glicitin-related polypeptide, glucagon, GLP-1 and GLP-2. Proglucagon exists in a variety of tissue cells, including pancreatic islet alpha cells, small intestine L cells and some neuronal cells. Due to the tissue specificity and post-translational processing of proglucagon, its cleavage products in different tissues are different. For example, glucagon is only produced in islet alpha cells. GLP-1 can be secreted by pancreatic islet α cells and some neuronal cells, or by enteroendocrine L cells in the terminal ileum and colon. While GLP-2 is generally secreted by enteroendocrine L cells and some neuronal cells. The main function of GLP-1 is to participate in sugar metabolism and energy metabolism. GLP-1 is an incretin hormone secreting insulin, which can promote insulin secretion and inhibit glucagon secretion, thereby helping to control the glucose homeostasis. In addition to acting on insulin and glucagon, GLP-1 can also reduce hepatic glucose output, slow down gastric emptying, stimulate cell proliferation, and increase thermogenesis. GLP-1 is significantly associated with type 2 diabetes and obesity. GLP-2 is mainly involved in the related physiological mechanisms of intestinal function. It not only promotes the growth of intestinal epithelial cells by promoting proliferation and inhibiting apoptosis, but also improves intestinal function, slows down gastrointestinal motility, and reduces intestinal damage. GLP-2 is significantly related to intestinal diseases such as inflammatory bowel disease and short bowel syndrome. GLPs are related to many diseases and can be used to study the mechanism of these diseases.
Figure 1. Schematic diagram of the pleiotropic local and systemic actions of GLP-1 and GLP-2 (Drucker, et al. 2017)
Our Services
Our Advantages
- Guarantee high accuracy and sensitivity for GLP detection
- Ensure high repeatability of GLP detection
- Short turn-around time of detection service
- Competitive price in the market of GLP detection services
Workflow of GLP Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the GLP-1 and GLP-2 detection procedure to ensure accurately quantify the level of GLPs in each sample.
At Creative BioMart Biomarker, we offer GLP-1 and GLP-2 detection services that include several technical methods, you can communicate with our experts according to your research needs, and we will determine the final detection technical scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
Reference:
- Drucker, D.J.; et al. Discovery, characterization, and clinical development of the glucagon-like peptides. Journal of Clinical Investigation. 2017, 127(12): 4217-4227.
