Fibrinogen Detection Service
Fibrinogen is a glycoprotein associated with the coagulation process, and its expression level increases in inflammation. Fibrinogen has a key role in activating and mediating the inflammatory process, and its expression level can reflect the changes of inflammatory diseases. Fibrinogen is an important biomarker in the research of many inflammatory diseases. As a reliable partner of biomarker researchers, Creative BioMart Biomarker has been providing customers with sensitive fibrinogen testing services. Fast and accurate detection can effectively help customers shorten the research cycle and reduce research costs.
Fibrinogen and Inflammation
Fibrinogen is a 340kDa soluble glycoprotein synthesized in the liver, composed of the Aα, Bβ and γ chains. During the coagulation process, the N-terminus of Aα and Bβ chains is cleaved by thrombin, releasing fibrinopeptides A (FpA, Aα1-16) and B (Bβ1-15), exposing the polymerization site and interacting with the complementary binding pocket in the D domain to trigger fibrin polymerization. Coagulation is a physiological process related to inflammation initiated by the activation of thrombin. Fibrinogen plays a key role in the acute phase response caused by tissue injury. It can not only participate in the inflammatory response by inducing the migration of leukocytes, but also regulate the inflammatory response by affecting the production of cytokines/chemokines. Fibrinogen is a ligand for a variety of cell surface receptors, which can promote intercellular adhesion for leukocytes and endothelial cells. In addition, fibrinogen can affect physiological processes such as phagocytosis, NF-κB-mediated transcription and degranulation. Fibrinogen is not only associated with intense and destructive tissue inflammation, it is also a driving factor for chronic low-grade inflammation. Elevated fibrinogen levels can be used as a biomarker to indicate the severity of inflammatory diseases and the risk of disease progression, while low levels may be related to fibrinolysis and liver disease.
Figure 1. Fibrinogen, thrombin and fibrinolytic protein in the mechanism of inflammation (Luyendyk, et al. 2019)
Application of Fibrinogen Detection
Fibrinogen levels can be used as biomarkers in researches related to appendicitis, periodontitis, sepsis, chronic obstructive pulmonary disease, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for fibrinogen detection
- Ensure high repeatability of fibrinogen detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, tissue homogenate, etc.
- Target species: human, rat, rabbit, mouse, goat, bovine, canine, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer fast and reliable fibrinogen detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Luyendyk, J. P.; et al. The multifaceted role of fibrinogen in tissue injury and inflammation. Blood. 2019, 133(6): 511-520.
- Jennewein, C.; et al. Novel aspects of fibrin(ogen) fragments during inflammation. Molecular Medicine. 2011, 17(5-6): 568-573.
