Fibrin/fibrinogen degradation products (FDP) are a digestive product of fibrinogen and fibrin clot, and its concentration increases in inflammatory diseases such as sepsis, periodontitis, and rheumatoid arthritis. FDP can be used as a potential biomarker in the research of inflammatory diseases. As an expert in the field of biomarker testing services, Creative BioMart Biomarker provide accurate and fast FDP testing services for biomarker researchers and are committed to helping customers accelerate the progress of FDP researches.
FDP and Inflammation
Inflammation is a complex response to infection or injury that occurs in the human body. The inflammatory process is related to the activation of the coagulation system, and coagulation is initiated by the activation of thrombin, which is related to the formation of fibrin. Fibrinogen/fibrin and FDP are coagulation factors that can regulate the inflammatory response by affecting the migration of leukocytes and the production of cytokines. Fibrinogen is a soluble glycoprotein formed in the liver. During the coagulation process, thrombin cleaves fibrinogen, releasing fibrinopeptides A (FpA, Aα1-16) and B (Bβ1-15), exposing the polymerization site and triggering fibrin polymerization. Thrombin activates coagulation factors and catalyzes the formation of isopeptide bonds between γ chains to stabilize fibrin clots. Fibrin can be cleaved at different sites by activated plasmin to produce different fragments, including X and Y fragments, D-dimers, D and E fragments, Bβ15-42, and other smaller fragments. Among them, D-dimers is a biomarker that can be used for fibrinolysis and disseminated intravascular coagulation (DIC). And it triggers the release of IL-1β, IL-6 and plasminogen activator inhibitor in peripheral blood mononuclear cells. During inflammation, E fragment can bind to VE-cadherin to induce cytokine expression and leukocyte migration. The increase in the expression level of FDP indicates the activation of coagulation and fibrinolysis, so it is used in the study of chronic inflammatory diseases.
Figure 1. Structure of fibrin(ogen) and its cleavage sites (Jennewein, et al. 2011)
Application of FDP Detection
FDP levels can be used as biomarkers in researches related to sepsis, periodontitis, rheumatoid arthritis, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for FDP detection
- Ensure high repeatability of FDP detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, tissue homogenate, etc.
- Target species: human, rat, rabbit, mouse, chicken, canine, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer accurate and reliable FDP detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
Reference:
- Jennewein, C.; et al. Novel aspects of fibrin(ogen) fragments during inflammation. Molecular Medicine. 2011, 17(5-6): 568-573.
