Factor D Detection Service

Factor D (also known as adipsin) is an important component of the complement system and is mostly used in the research of chronic inflammatory diseases and inflammation-related diseases such as obesity and type 2 diabetes. FD is a potential biomarker for the diagnosis and monitoring of inflammatory diseases. Creative BioMart Biomarker has many years of experience in biomarker testing and can provide customers with accurate and reliable FD detection services. Fast test, reliable results and reasonable prices can effectively help customers shorten the research cycle and reduce research costs.

Factor D (Adipsin)

FD is a protein encoded by the human CFD gene and secreted by adipocytes, which participates in the activation pathway in the complement system. The complement system is a part of the human immune system and a defense system for humans against microbial invaders. The complement system involves dozens of components, including pattern-recognition molecules (PRM), proteases, protein components, regulators, cell surface receptors, etc. When faced with foreign invaders, the combination of PRM and molecular surface patterns can trigger different initial pathways. The activation pathways of the complement system include the classical pathway (CP), the lectin pathway (LP) and the alternative pathway (AP). In AP, FD can cleave factor B (FB) into Ba and Bb, and occupies an important position in this pathway. FB, FD and properdin (FP) can promote the enhancement of AP activation. The cleavage product C3b of C3 can covalently bind to the surface of microorganisms and bind to FB to form C3bB. FD can cleave the complex to produce C3 convertase C3bBb, which then promotes subsequent degradation and activation events. Therefore, FD is closely related to the formation of C3 convertase and participates in the regulation of AP in the complement system. There is a correlation between the complement system and many diseases. Both complement deficiency and excessive complement activation are related to the pathogenesis of inflammatory diseases. For example, FD is often used as a research object in the research of chronic inflammation-related diseases such as obesity and type 2 diabetes.

Activation of the alternative complement pathwayFigure 1. Activation of the alternative complement pathway (Shahini, et al. 2017)

Application of Factor D Detection

FD levels can be used as biomarkers in researches related to obesity, type 2 diabetes, etc.

Our Advantages

  • Guarantee high accuracy and sensitivity for FD detection
  • Ensure high repeatability of FD detection
  • Short turn-around time of detection service
  • Competitive price in the market of FD detection services
  • Multiple technology platforms for FD test services (ELISA, CLIA)
  • Accept a wide range of sample types (plasma, serum, tissue homogenate, etc.)

Workflow of Biomarker Detection at Creative BioMart Biomarker

Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of FD in each sample.

Workflow

At Creative BioMart Biomarker, we offer high-quality FD detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.

References:

  1. Ricklin, D.; Lambris, J. D. Complement in immune and inflammatory disorders: pathophysiological mechanisms. Journal of Immunology. 2013, 190(8): 3831-3838.
  2. Wu, X.; et al. Contribution of adipose-derived factor D/adipsin to complement alternative pathway activation: lessons from lipodystrophy. Journal of Immunology. 2018, 200(8): 2786-2797.
  3. Shahini, N.; et al. The alternative complement pathway is dysregulated in patients with chronic heart failure. Molecular Immunology. 2017, 7: 42532.

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