E-selectin Detection Service
E-selectin is a membrane-bound adhesion molecule that can be rapidly induced and upregulated by inflammatory cytokines. It plays an important role in the inflammatory response. Therefore, E-selectin is often used in the research of inflammatory diseases. Creative BioMart Biomarker has service experience for many years, and can provide customers with sensitive and specific E-selectin testing service. Accurate and reliable results, short turnaround time and reasonable prices can effectively help customers shorten the research cycle and reduce research costs.
E-selectin
E-selectin, also known as endothelial-leukocyte adhesion molecule 1, CD62 antigen-like family member E, or leukocyte-endothelial cell adhesion molecule 2, is a member of the selectin family. Selectin is a single-chain transmembrane glycoprotein that can be expressed on endothelial cells, leukocytes and platelets, and has similar properties to C-type lectins. The selectin family has similar domains, including C-type lectin domain, epidermal growth factor-like domain, short consensus repeats (the number of repeat units in E-selectin is 6), a transmembrane region and a cytoplasmic domain. Selectins can regulate leukocyte recruitment and play an important role in inflammation. E-selectin is a type of selectin expressed on activated endothelial cells and can be rapidly induced by inflammatory cytokines. The expression of E-selectin is precisely regulated and is closely related to the recruitment of white blood cells in the early stage of inflammation. Under normal physiological conditions, the expression level of E-selectin is low. In inflammation, tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and lipopolysaccharide (LPS) can increase the expression level of E-selectin by promoting the transcriptional activation. E-selectin is an important selectin that transports white blood cells to the inflammation site, and also plays a key role in the process of recruiting immune factors to target the inflammation site. E-selectin can be used to monitor the activity of inflammatory diseases and can be used as a potential biomarker for the research of various diseases.
Figure 1. The selectin family (Silva, et al. 2017)
Application of E-selectin Detection
E-selectin levels can be used as biomarkers in researches related to atopic dermatitis, atherosclerosis, cancer, neuro inflammation, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for E-selectin detection
- Ensure high repeatability of E-selectin detection
- Short turn-around time of detection service
- Competitive price in the market of E-selectin detection services
- Multiple technology platforms for E-selectin test services (ELISA, ECL)
- Accept a wide range of sample types (plasma, serum, cell culture supernatants, etc.)
Workflow of Biomarker Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of E-selectin in each sample.
At Creative BioMart Biomarker, we offer high-quality E-selectin detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Silva, M.; et al. E-selectin ligands in the human mononuclear phagocyte system: implications for infection, inflammation, and immunotherapy. Frontiers in Immunology. 2017, 8: 1878.
- Milstone, D. S.; et al. E-selectin expression and stimulation by inflammatory mediators are developmentally regulated during embryogenesis. Laboratory Investigation. 2000, 80(6): 943-954.
