Complement component 3 (C3) is a pro-inflammatory molecule belonging to the complement system and has a key position in the pathway of complement activation. Its expression level in the blood has research significance for medical diagnosis of diseases, such as C3 glomerulopathy (C3G) and other types of inflammatory diseases. Creative BioMart Biomarker provides customers with accurate, sensitive and specific C3 testing services. High-quality services, short turnaround time and reasonable prices can effectively help customers shorten the research cycle and reduce research costs.
C3 is a plasma protein with a central position in the complement system. When the complement system is activated, it will undergo conformational changes, exposing multiple sites that can interact with immune effectors. The activation pathways of the complement system include the classical pathway (CP), the lectin pathway (LP) and the alternative pathway (AP). C3 plays an important role in the three complement activation pathways. Each activation pathway has different recognition molecules, which can bind to the structure existing on the pathogen, and then activate C1r and C1s in CP, as well as MASP-1 and MASP-2 in LP, respectively. These proteases can initiate the assembly of C4bC2a in CP and LP. The activation of AP is dependent on conformationally altered C3, which induces the formation of C3bBbP. C3 convertase (C4bC2a and C3bBbP) cleaves C3 into the anaphylatoxin C3a and the opsonin C3b, causes further lysis and activation events to occur. The complement system is involved in a variety of diseases. Complement deficiency and excessive complement activation are all related to the pathogenesis of inflammatory diseases. As a key molecule in the complement system, the level of C3 in the blood can be used to assist medical diagnosis and is a monitoring and diagnostic biomarker for diseases such as C3G and systemic lupus erythematosus (SLE).
Figure 1. Overview of the complement system (Ekdahl, et al. 2018)
C3 levels can be used as biomarkers in researches related to C3G, SLE, antibody mediated rejection in transplantation (AMR), poststreptococcal glomerulonephritis (PSGN), etc.
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of C3 in each sample.
At Creative BioMart Biomarker, we offer high-quality C3 detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.