Complement Component 3 Detection Service
Creative BioMart Biomarker offers complement component 3 (C3) detection outsourcing services for researchers. The service results ensure accuracy, specificity and repeatability. Our testing services are only suitable for scientific research, not intended for clinical diagnosis and testing.
|
Complement Component 3 Testing |
| Analyte: |
complement component 3 |
| Synonyms: |
C3 |
| Sample Type: |
plasma, serum, cell culture supernatants or other biological fluids |
| Assay Platform: |
ELISA, CLIA |
| Biomarker Application Area: |
C3 glomerulopathy (C3G), systemic lupus erythematosus (SLE), antibody mediated rejection in transplantation (AMR), poststreptococcal glomerulonephritis (PSGN), etc. |
| * Perform three replicate tests on each sample, and include appropriate controls in each assay. |
Assay Background
C3 is a plasma protein with a central position in the complement system. When the complement system is activated, it will undergo conformational changes, exposing multiple sites that can interact with immune effectors. The activation pathways of the complement system include the classical pathway (CP), the lectin pathway (LP) and the alternative pathway (AP). C3 plays an important role in the three complement activation pathways. Each activation pathway has different recognition molecules, which can bind to the structure existing on the pathogen, and then activate C1r and C1s in CP, as well as MASP-1 and MASP-2 in LP, respectively. These proteases can initiate the assembly of C4bC2a in CP and LP. The activation of AP is dependent on conformationally altered C3, which induces the formation of C3bBbP. C3 convertase (C4bC2a and C3bBbP) cleaves C3 into the anaphylatoxin C3a and the opsonin C3b, causes further lysis and activation events to occur. The complement system is involved in a variety of diseases. Complement deficiency and excessive complement activation are all related to the pathogenesis of inflammatory diseases.
Workflow of Biomarker Detection Services at Creative BioMart Biomarker
Customers provide: samples, reagents/kits (reagents/kits can also be provided or purchased by our company).
We provide: remaining samples and reagents, complete experimental reports (including experimental raw data, experimental procedures, instrument and reagent information, and professional result analysis).
Test cycle: 10 working days or less.
Why Choose Creative BioMart Biomarker for C3 Detection Service?
- High-quality technology platform
Creative BioMart Biomarker provides two technology platforms for C3 testing, CLIA and ELISA. For the detection of biomarkers, our experts have optimized the technology platform to improve the sensitivity and specificity of the detection.
- Experienced experts team
We have many experts with rich experience in biomarker testing. They always treat each test with a rigorous attitude and can always provide customers with accurate, precise and repeatable test results.
- Suitable for multiple sample types
Our biomarker testing service is applicable to several sample types, including serum, plasma, cell culture supernatant, etc. If your sample type is not common, you can contact us at any time to inquire about the testing service for your sample type.
- Fast testing and reasonable price
We have been committed to providing customers with efficient services to ensure that the experimental results are delivered within the predetermined time. Our testing services have reasonable and competitive prices in the industry, which can help customers reduce research costs.
If you are interested in our services, please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
Reference:
- Ekdahl, K. N.; et al. Interpretation of serological complement biomarkers in disease. Frontiers in Immunology. 2018, 9: 2237.
