Cholesterol Ester Transfer Protein (CETP), also known as the plasma lipid transfer protein, is a plasma protein that promotes the exchange of cholesterol esters and triglycerides between high density proteins (HDL) and apolipoprotein B100- containing lipoprotein particles. The concentration and activity of plasma CETP correlate with the concentration of HDL-C and is also used to predict the risk of atherosclerosis and cardiovascular events. Creative BioMart Biomarker is capable to provide our customers with superior CETP detection service, various detection methods ensuring high sensitivity for detecting biomarkers in different samples with different concentrations.
Introduction
CETP is primarily bound with high density lipoprotein (HDL) in the circulation. CETP can equimolar transfer neutral lipids, including cholesterol ester (CE) and triglycerides (TG), between plasma HDL and apolipoprotein B100-containing lipoprotein particles. The net effect of CETP is to transfer CE from HDL to very low density lipoprotein (VLDL) and low density lipoprotein (LDL), shifting TG in the opposite direction. In humans and monkeys, CETP is mainly expressed in the liver, small intestine, adipose tissue and spleen. In human plasma, the concentration of CETP is approximately 2 μg/ml, and is higher in subjects with dyslipidemia, which is mainly associated with HDL. Plasma cholesterol ester transfer activity depends on CETP concentration and the ability of CETP to interact with lipoproteins. Studies have shown that when CETP levels are inhibited, the level of HDL-C is significantly increased, thereby reducing the risk of atherosclerosis. The opposite study found that when HDL-C levels were higher, CETP levels were lower and cardiovascular risk was lower. At the same time, when CETP activity is low, there are fewer cardiovascular events. Therefore, by measuring the concentration and activity of plasma CETP, the level of HDL-C can be predicted to predict the probability of disease occurrence.
Figure 1. The mechanism of CETP.
Application of CETP
- Serum, plasma levels and activity of CETP can be used as a biomarker to predict the level of HDL-C and the risk of atherosclerosis and cardiovascular events.
Our Advantages
- Accept a wide range of sample types
- Provide multiple detection methods
- Ensure high sensitivity for detecting CETP in different samples
- Ensure high accuracy and repeatable CETP detection
- Ensure a wide kinetic range to detect samples of different concentrations
- Short experimental period
Workflow of CETP Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the CETP detection procedure to ensure high sensitivity, high accuracy and repeatable CETP detection.
Please feel free to contact us if you would like to know more about CETP detection. At Creative BioMart Biomarker, we not only provide high-quality CETP detection service, but also provide detection services for other biomarkers. Additionally, our experts can also provide and help design the best solution according to your specific requirements.
References:
- Armitage, J.; et al. Cholesteryl ester transfer protein inhibition for preventing cardiovascular events. J Am Coll Cardiol. 2019, 73(4): 477-487.
- Masson, D.; et al. The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis. J Lipid Res. 2009, Suppl: S201-6.
- Nicholls, S.J. CETP-inhibition and HDL-cholesterol: A story of CV risk or CV benefit, or both. Clin Pharmacol Ther. 2018, 104(2): 297-300.
