Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell interaction, cell adhesion, and immune response. It is abnormally expressed in a variety of cancers and is a broad-spectrum cancer biomarker that can be used in conjunction with other biomarkers for cancer research. Creative BioMart Biomarker provides customers with accurate, sensitive and specific cancer biomarker testing services, including CEA detection services. High-quality services, short turnaround time and reasonable prices can effectively help customers shorten the research cycle and reduce research costs.
CEA belongs to the immunoglobulin (Ig) superfamily, and it is also a glycoprotein involved in cell adhesion and plays a role in cell interaction and cell recognition. CEA is also called CEACAM5 or CD66e, and its gene family includes 29 genes/pseudogenes. According to sequence similarity and function, CEA can be divided into the CEA-related cell adhesion molecule (CEACAM) group, pregnancy-specific glycoprotein (PSG) group, and pseudogene group. The extracellular domain of the CEACAM group has the role of cell adhesion molecules or receptors. The CEACAM group contains 12 kinds of proteins, among which CEACAM1, CEACAM5, and CEACAM6 are all related to cancer progression. CEA has GPI-linked membrane anchoring properties, and its membrane-fixed region can be cleaved by phospholipase C and phospholipase D, and the cleaved product is released into the blood circulation system. CEA is related to various physiological functions in the body, such as cell adhesion, immune response and anoikis resistance. CEA is a broad-spectrum tumor biomarker with abnormal expression in a variety of malignant tumors, including colorectal cancer, breast cancer, gastric cancer, liver cancer, and lung cancer. At the same time, CEA expression levels can be used for cancer recurrence and tumor metastasis monitoring, as well as clinical staging. In addition, the increase in CEA concentration is also associated with inflammatory diseases. Although CEA is not recommended as a specific biomarker for a certain tumor, it still has clinical value. CEA can be used for therapeutic effect monitoring and prognostic evaluation, and can be used in combination with other biomarkers for cancer diagnosis.
Figure 1. Schematic representation of CEACAM group members (Lee, et al. 2017)
Plasma and serum CEA levels can be used as biomarkers in researches related to colorectal cancer, breast cancer, stomach cancer, liver cancer, lung cancer, etc.
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of CEA in each sample.
At Creative BioMart Biomarker, we offer high-quality CEA detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.