Bone morphogenetic protein 9 (BMP-9) is a growth factor associated with angiogenesis, tumorigenesis, and metastasis. It is a potential biomarker for a variety of cancers, and its effectiveness as a cancer biomarker needs to be further explored. Creative BioMart Biomarker provides customers with accurate, sensitive and specific cancer biomarker testing services, including BMP-9 detection services. High-quality services, short turnaround time and reasonable prices can effectively help customers shorten the research cycle and reduce research costs.
BMP-9 and Cancers
Bmp-9 is an effective growth factor, which is also known as growth differentiation factor 2 (GDF2). The BMP family includes multiple subtypes (BMP-2, BMP-4, BMP-6, BMP-7, BMP-9, BMP-10, etc.), mostly associated with cancer progression and metastasis. BMP-9 is associated with multiple physiological activities such as iron homeostasis, hepatocyte growth, glucose and fatty acid metabolism, bone formation, cholinergic neuronal differentiation, angiogenesis, tumor progression, etc. BMP-9 belongs to the transforming growth factor beta (TGF-β) superfamily. The TGF-β family is composed of multiple functional proteins that can activate downstream signal transduction cascades such as the ALK-Smad pathway. The activation of these pathways (e.g. ALK5–Smad2/3 and ALK1–Smad1/5/8 pathways) may lead to the inhibition or activation of endothelial cell migration and proliferation. BMP-9 can bind with high affinity to its specific type I receptor, activin receptor-like kinase 1 (ALK1), and induce the phosphorylation of Smad1/5, at the same time, inhibit the proliferation and migration of endothelial cells induced by basic fibroblast growth factor (FGF) and angiogenesis induced by vascular endothelial growth factor (VEGF). The ALK1 pathway is involved in vascular development and pathological angiogenesis, and angiogenesis plays a key role in tumor progression. Abnormal expression of BMP-9 has been found in various types of cancer, such as ovarian tumors, hepatocellular carcinoma, prostate cancer, breast cancer, etc., and these abnormal expressions are related to the occurrence and metastasis of cancer.
Figure 1. BMP-9/Smad signaling (Mostafa, et al. 2019)
Application of BMP-9 Detection
Plasma and serum BMP-9 levels can be used as biomarkers in researches related to ovarian tumors, hepatocellular carcinoma, prostate cancer, breast cancer, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for BMP-9 detection
- Ensure high repeatability of BMP-9 detection
- Short turn-around time of detection service
- Competitive price in the market of BMP-9 detection services
- Multiple technology platforms for BMP-9 test services (ELISA, CLIA)
- Accept a wide range of sample types (plasma, serum, cell culture supernatants, etc.)
Workflow of Biomarker Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of BMP-9 in each sample.
At Creative BioMart Biomarker, we offer high-quality BMP-9 detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Suzuki, Y.; et al. BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. Journal of Cell Science. 2010, 123(10): 1684-92.
- Brand, V.; et al. Impact of selective anti-bmp9 treatment on tumor cells and tumor angiogenesis. Molecular Oncology. 2016, 10(10): 1603-1620.
- Mostafa, S.; et al. The wonders of BMP9: from mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine. Genes & Diseases. 2019, 6(3): 201-223.
