A proliferation-inducing ligand (APRIL) is a protein that is abnormally expressed in a variety of autoimmune diseases and cancers, and it has been studied as a candidate biomarker in various cancer related studies. Creative BioMart Biomarker provides customers with accurate, sensitive and specific cancer biomarker testing services, including APRIL detection services. High-quality services, short turnaround time and reasonable prices can effectively help customers shorten the research cycle and reduce research costs.
APRIL and Cancers
APRIL is one of the members of the tumor necrosis factor (TNF) superfamily, also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13) and TRDL-1. APRIL has a high homology with B-cell activating factor (BAFF), which is another member of the TNF family. Both of them play an important role in the researches of autoimmune diseases and cancers. BAFF can bind to three receptors: B cell activating factor receptor (BAFF-R), B-cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), while APRIL binds to BCMA and TACI. BAFF and APRIL have important effects on various immune functions, including the maturation and differentiation of B cells and the production of antibodies. APRIL not only have abnormal expression in autoimmune diseases (the mRNA levels in patients are higher than those in the normal population), but also have abnormal expression in various tumor diseases. For example, in non-small cell lung cancer (NSCLC), the expression level of APRIL is up-regulated, and researchers believe that APRIL has potential as a diagnostic biomarker for NSCLC. In addition, APRIL is related to the growth and apoptosis of certain tumor cells. It has also been studied whether it can be used as an effective biomarker for other cancers, including gastric cancer, primary central nervous system lymphoma (PCNSL), colorectal adenocarcinoma, pancreatic adenocarcinoma, etc.
Figure 1. BAFF, APRIL and their receptors (Mackay, et al. 2009)
Application of APRIL Detection
Plasma and serum APRIL levels can be used as biomarkers in researches related to NSCLC, PCNSL, gastric cancer, pancreatic adenocarcinoma, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for APRIL detection
- Ensure high repeatability of APRIL detection
- Short turn-around time of detection service
- Competitive price in the market of APRIL detection services
- Accept a wide range of sample types (plasma, serum, tissue homogenates, cell culture supernatant)
Detection Technology
Workflow of Biomarker Detection at Creative BioMart Biomarker
Creative BioMart Biomarker strictly controls each specific experimental step in the detection procedure to ensure accurately quantify the level of APRIL in each sample.
At Creative BioMart Biomarker, we offer high-quality APRIL detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
References:
- Polverino, F.; et al. Increased expression of a proliferation-inducing ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non-small cell lung cancer: a possible link between COPD and lung cancer?. Multidiscip Respir Med. 2016, 11: 17.
- Mackay, F.; Schneider, P. Cracking the BAFF code. Nature Reviews Immunology. 2009, 9: 491–502.
