Angiopoietin-2 Detection Service
Angiopoietin-2 (Ang-2) is a growth factor that participates in both innate immunity and adaptive immunity, and can promote inflammation and the activation of the immune system. Ang-2 has scientific research prospects in the research of autoimmune diseases, tumors, cardiovascular diseases, and the development of new drugs, and has been studied as a biomarker. Creative BioMart Biomarker has a wealth of biomarker detection experience and can provide customers with fast and accurate Ang-2 detection services, meet customer research needs and help customers accelerate research progress.
Angiopoietin-2
Ang-2 is a highly active octapeptide produced by the cleavage of angiotensin I. Ang-2 is a typical cardiovascular mediator that plays an important role in regulating blood pressure and fluid homeostasis. Ang-2 receptors mainly exist on lymphocytes and macrophages, including AT1R and AT2R. A single AT1R is expressed in human cells, but there are two subtypes of AT1AR and AT1BR in mouse and rats, among which AT1AR has higher homology with human AT1R. AT1R consists of 359 amino acids and is an activator of the Gq/11 family. Ang-2 mainly induces its pro-stress and proinflammatory effects by stimulation of AT1R, so AT1R blockers have anti-inflammatory effects. AT2R is composed of 363 amino acids and can activate protein tyrosine phosphatase. AT2R may have anti-proliferation, anti-inflammatory and anti-fibrosis effects. Ang-2 acts as a regulator in innate immunity and may activate innate immunity and adaptive immunity. Natural killer cells may produce Ang-2 and deliver it to the site of inflammation. The interaction between Ang-2 and AT1R can promote the migration of neutrophils and stimulate the interaction between leukocytes and endothelial cells. Dendritic cells can express AT1R and AT2R, the activation of the cells can mediate the immune activity of Ang-2, and the combination of AT1R and Ang-2 can enhance the migration, maturation and antigen-presenting capabilities of dendritic cells.
Figure 1. The roles of Ang-2 on innate and adaptive immunity (Chang, et al. 2015)
Application of Angiopoietin-2 Detection
Angiopoietin-2 levels can be used as biomarkers in researches related to autoimmune diseases, tumors, cardiovascular diseases, sepsis, etc.
Our Advantages
- Guarantee high accuracy and sensitivity for Ang-2 detection
- Ensure high repeatability of Ang-2 detection
- Experienced biomarker detection technical team
- Strictly control each specific experimental step to ensure accurate and reliable test results in each sample
- Short turnaround time to accelerate your research
- More favorable prices in the biomarker testing service market can help reduce research costs
Detection Technologies
Samples
- Sample types: serum, plasma, cell culture supernatants, etc.
- Target species: human, mouse, bovine, rat, canine, rabbit, etc.
Workflow of Biomarker Detection at Creative BioMart Biomarker
At Creative BioMart Biomarker, we offer high-quality Ang-2 detection service that ensuring the sensitivity and specificity of test results. You can also talk to our experts according to your certain requirement, and we will determine the final detection scheme based on the communication results. Please feel free to contact us, Creative BioMart Biomarker is here to offer you professional and thoughtful service.
Reference:
- Chang, Y.; Wei, W. Angiotensin II in inflammation, immunity and rheumatoid arthritis. Clinical & Experimental Immunology. 2015, 179(2): 137-145.
