| Catalog#: |
MK0759H |
| Product Name: |
Recombinant Human TPO, His tagged |
| Product Overview: |
Recombinant Human TPO (P07202-1) extracellular domain (Met 1- Arg846, 257 Ser/Ala, 725 Pro/Thr), fused with a polyhistidine tag at the C-terminus, was produced in Baculovirus-Insect cells. |
| Description: |
Thyroid peroxidase, also known as TPO, is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It acts as an enzyme and plays a central role in thyroid gland function. Thyroid peroxidase/TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in thyroid peroxidase/TPO gene are associated with several disorders of thyroid ho |
| Source: |
Baculovirus-Insect cells |
| Species: |
Human |
| Tag: |
His |
| Formulation: |
Lyophilized from 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH 7.4, 10% gly |
| Storage: |
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4°C before opening to recover the entire contents. |
| Molecular Mass: |
The secreted recombinant human TPO comprises 842 amino acids and has a predicted molecular mass of 93.8 kDa. ? The apparent molecular mass of rh TPO (1-846) is approximately 90-100 kDa in SDS-PAGE under reducing conditions. |
| Stability: |
Samples are stable for up to twelve months from date of receipt at -70℃. |
| Endotoxin: |
Less than 1.0 EU per μg as determined by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures.Aoid repeated freeze-thaw cycles. |
