| Catalog#: |
MK1268H |
| Product Name: |
Recombinant Human PSMA Protein, His-tagged |
| Description: |
Prostate-specific membrane antigen (PSMA) also known as Folate hydrolase 1 (FOLH1), Folylpoly-gamma-glutamate carboxypeptidase (FGCP), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), is a type II membrane glycoprotein that is expressed in prostate tissue and to a lesser extent in the peripheral and central nervous system, small intestinal, and salivary gland tissues. PSMA has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. The catalytic activity of PSMA involves the release of unsubstituted C-terminal glutamyl residues, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer’s disease, and Huntington’s disease. |
| Source: |
CHO 3E7 cells |
| Species: |
Human |
| Tag: |
His |
| Formulation: |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
| Protein length: |
Lys44-Ala750 |
| Purity: |
> 85% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20 °C to -80 °C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/mL. |
| Molecular Mass: |
90-120 kDa |
| Stability: |
Upon receiving, this product remains stable for 6 months at lower than -70 °C. Upon reconstitution, the product should be stable for 1 week at 4 °C or for 3 months at -20 °C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. |
| Endotoxin: |
< 1 EU/μg of protein by gel clotting method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. |
