| Description: |
Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II). Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.It has been reported that human Pepsinogen I (PGA)levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer. |
