| Product Name: |
Recombinant Human NKG2D/CD314, His-Avi-tagged |
| Catalog#: |
MK1031H |
| Species: |
Human |
| Source: |
HEK293 |
| Tag: |
His-Avi |
| Product Overview: |
Recombinant Human NKG2D/CD314 (P26718) (Phe78-Val216), fused with a N-terminal His-Avi tag, was expressed in HEK293 cells. |
| Description: |
NKG2D is an activating receptor expressed on the surface of key immune cells, including NK cells and various T cells. It functions as a critical part of the immune system's surveillance mechanism by recognizing specific ligands (like MICA, MICB, and ULBPs) that appear on cells under stress, such as during a viral infection or cancerous transformation. Upon binding these ligands, NKG2D sends an activating signal to the immune cell, triggering it to eliminate the targeted stressed or tumor cell. This role makes NKG2D a central player in both anti-tumor and anti-viral immunity. |
| Formulation: |
Formulated in 0.22μm-filtered Phosphate-Buffered Saline (pH 7.4). |
| Purity: |
> 95% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Use distilled water to dissolve the protein to a concentration above 100 μg/mL. Aliquot the solution into single-use vials and freeze. |
| Molecular Mass: |
Approximately 19 kDa. |
| Stability: |
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. |
| Endotoxin: |
Less than 1.0 EU per μg as determined by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. Aoid repeated freeze-thaw cycles. |
