| Product Name: |
Recombinant Human Kallikrein 5/KLK5 Protein (active form), His-Flag tagged |
| Catalog#: |
MK1124H |
| Species: |
Human |
| Source: |
HEK293 |
| Tag: |
His-Flag |
| Product Overview: |
Recombinant Human Kallikrein 5/KLK5 Protein (active form) (Q9Y337) (Ile67-Ser293), fused with a C-terminal His-Flag tag, was expressed in HEK293 cells. |
| Description: |
Inhibiting kallikrein 5 (KLK5) is a potential treatment for Netherton syndrome, a genetic skin disorder caused by SPINK5 gene mutations. These mutations reduce the endogenous inhibitor LEKTI-1, leading to severe skin-barrier defects and allergies. To develop a medicine targeting KLK5, an X-ray crystallography system was created to support fragment-based chemistry and knowledge-driven drug discovery. |
| Formulation: |
Formulated in 0.22μm-filtered Phosphate-Buffered Saline (pH 7.4). |
| Purity: |
> 95% as determined by SDS-PAGE. |
| Storage: |
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Use distilled water to dissolve the protein to a concentration above 100 μg/mL. Aliquot the solution into single-use vials and freeze. |
| Molecular Mass: |
The protein has a predicted MW of 31.7 kDa. |
| Stability: |
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. |
| Endotoxin: |
Less than 1.0 EU per μg as determined by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. Aoid repeated freeze-thaw cycles. |
