| Catalog#: |
MK0933H |
| Product Name: |
Recombinant Human IDO1 Protein, His/Avi-tagged |
| Product Overview: |
Human IDO1, also known as Indoleamine 2,3-dioxygenase 1, a.a. 2-403(end) with an N-terminal His-Avi-Tag, was expressed in an E. coli cell expression system. |
| Description: |
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. |
| Source: |
E. coli |
| Species: |
Human |
| Tag: |
His/Avi |
| Formulation: |
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04 % Tween 20, 20 % glycerol |
| Storage: |
At -80 centigrade |
| Molecular Mass: |
48 kDa |
| Stability: |
At least 6 months at -80 centigrade |
