| Catalog#: |
MK1231H |
| Product Name: |
Recombinant Human GLP-1R Protein, mFc Chimera |
| Description: |
The GLP1R, a GPCR, is found on pancreatic beta cells and brain neurons. It regulates blood sugar by enhancing insulin secretion. In humans, it is encoded by the gene GLP1R on chromosome 6. GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of GLP-1 and a transmembrane domain that binds the N-terminal region of GLP-1. The TMD domain contains polar residues that regulate biased signaling, while the transmembrane helical boundaries and extracellular surface trigger biased agonism. |
| Source: |
HEK293 cells |
| Species: |
Human |
| Tag: |
Fc |
| Formulation: |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
| Protein length: |
Arg24-Glu139 |
| Purity: |
> 95% as determined by Bis-Tris PAGE.
> 95% as determined by HPLC. |
| Storage: |
Store under sterile conditions at -20 °C to -80 °C. Avoid repeated freeze-thaw cycles. |
| Reconstitution: |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water. |
| Molecular Mass: |
39.20 kDa |
| Stability: |
Upon receiving, the product remains stable for 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Recommend to aliquot the protein into smaller quantities for optimal storage. |
| Endotoxin: |
Less than 1 EU per μg by the LAL method. |
| Notes: |
Research Use Only. Not for use in clinical procedures. |
